PMID- 28061834
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20181113
IS  - 1471-2466 (Electronic)
IS  - 1471-2466 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Jan 6
TI  - Prevalence of airflow obstruction in patients with stable systolic heart failure.
PG  - 6
LID - 10.1186/s12890-016-0351-9 [doi]
LID - 6
AB  - BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an important 
      differential diagnosis in heart failure (HF). However, routine use of spirometry 
      in outpatient HF clinics is not implemented. The aim of the present study was to 
      determine the prevalence of both airflow obstruction and non obstructive lung 
      function impairment in patients with HF and to examine the effect of optimal 
      medical treatment for HF on lung function parameters. METHODS: Consecutive 
      patients with HF (ejection fraction (EF) < 45%) and New York Heart Association 
      (NYHA) functional class II-IV at 10 different outpatient heart failure clinics 
      were examined with spirometry at their first visit and after optimal medical 
      treatment for HF was achieved. airflow obstruction was classified and graded 
      according to the GOLD 2011 revision. RESULTS: Baseline spirometry was performed 
      in 593 included patients and 71 (12%) had a clinical diagnosis of COPD. Mean age 
      was 69 +/- 11 years and mean EF was 30 +/- 9%. Thirty-two % of the patients were 
      active smokers and 53% were previous smokers. Mean FEV(1) and FVC was 77.9 +/- 1.7% 
      and 85.4 +/- 1.5% of predicted respectively. Obstructive pattern was observed in 
      233 (39%) of the patients. Of these, 53 patients (9%) had mild disease (GOLD I) 
      and 180 (30%) patients had moderate to very severe disease (GOLD II-IV). No 
      difference in spirometric variables was observed following up titration of 
      medication. CONCLUSION: In stable patients with HF airflow obstruction is 
      frequent and severely underdiagnosed. Spirometry should be considered in all 
      patients with HF in order to improve diagnosis and treatment for concomitant 
      pulmonary disease.
FAU - Dalsgaard, Morten
AU  - Dalsgaard M
AD  - Department of Cardiology, Herlev Hospital, Copenhagen University Hospital, Herlev 
      Ringvej 75, Copenhagen, Denmark. md@dadlnet.dk.
FAU - Plesner, Louis Lind
AU  - Plesner LL
AD  - Department of Cardiology, Herlev Hospital, Copenhagen University Hospital, Herlev 
      Ringvej 75, Copenhagen, Denmark.
FAU - Schou, Morten
AU  - Schou M
AD  - Department of Cardiology, Herlev Hospital, Copenhagen University Hospital, Herlev 
      Ringvej 75, Copenhagen, Denmark.
FAU - Kjoller, Erik
AU  - Kjoller E
AD  - Department of Cardiology, Herlev Hospital, Copenhagen University Hospital, Herlev 
      Ringvej 75, Copenhagen, Denmark.
FAU - Vestbo, Jorgen
AU  - Vestbo J
AD  - Department of Respiratory Medicine, Gentofte Hospital, Copenhagen University 
      Hospital, Copenhagen, Denmark.
AD  - Respiratory and Allergy Research Group, Manchester Academic Health Science 
      Centre, University Hospital South Manchester NHS Foundation Trust, Manchester, 
      UK.
FAU - Iversen, Kasper
AU  - Iversen K
AD  - Department of Cardiology, Herlev Hospital, Copenhagen University Hospital, Herlev 
      Ringvej 75, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20170106
PL  - England
TA  - BMC Pulm Med
JT  - BMC pulmonary medicine
JID - 100968563
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Denmark/epidemiology
MH  - Female
MH  - Forced Expiratory Volume
MH  - Heart Failure, Systolic/*complications
MH  - Humans
MH  - Logistic Models
MH  - Lung/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prevalence
MH  - Pulmonary Disease, Chronic Obstructive/*diagnosis/*epidemiology
MH  - Self Report
MH  - Smoking/epidemiology
MH  - Spirometry
MH  - Vital Capacity
PMC - PMC5219786
OTO - NOTNLM
OT  - COPD
OT  - Heart failure
OT  - Spirometry
EDAT- 2017/01/08 06:00
MHDA- 2017/11/03 06:00
PMCR- 2017/01/06
CRDT- 2017/01/08 06:00
PHST- 2015/11/02 00:00 [received]
PHST- 2016/12/14 00:00 [accepted]
PHST- 2017/01/08 06:00 [entrez]
PHST- 2017/01/08 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
PHST- 2017/01/06 00:00 [pmc-release]
AID - 10.1186/s12890-016-0351-9 [pii]
AID - 351 [pii]
AID - 10.1186/s12890-016-0351-9 [doi]
PST - epublish
SO  - BMC Pulm Med. 2017 Jan 6;17(1):6. doi: 10.1186/s12890-016-0351-9.