PMID- 28061998
OWN - NLM
STAT- MEDLINE
DCOM- 20170308
LR  - 20220310
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 198
DP  - 2017 Jan
TI  - Effects of Mycoplasma hyopneumoniae on porcine nasal cavity dendritic cells.
PG  - 1-8
LID - S0378-1135(16)30667-8 [pii]
LID - 10.1016/j.vetmic.2016.11.018 [doi]
AB  - Mycoplasma hyopneumoniae (Mhp) is the primary etiological agent responsible for 
      swine enzootic pneumonia (EP), a disease that cause tremendous economic losses 
      all over the swine industry. Dendritic cells (DCs), the most effective 
      antigen-presenting cells, are widely distributed beneath respiratory epithelium. 
      DCs uptake and present antigens to T cells, to initiate protective immune 
      responses or generate immune-mediated pathology in different infections. In this 
      study, we investigated the changes in the different DCs subpopulations, T cells 
      and SIgA positive cells counts in porcine nasal cavity after long time Mhp 
      infection. We further evaluated the role of porcine DCs in Mhp exposure. Our 
      results showed that the number of SLA-II-DR(+)SWC3a(+)DCs, SLA-II-DR(+)CD11b(+) 
      DCs, T cells, SIgA positive cells in nasal cavity were decreased after Mhp 28 
      days infection in vivo experiment. The antigen presenting ability of DCs were 
      inhibited by Mhp exposure. DCs couldn't activate T-cell proliferation by 
      down-regulating the antigen presenting molecule CD1a expression and promoting 
      high level of IL-10 production. Further more, the expression levels of IL-12 and 
      IFN-gamma in DCs were decreased, suggesting that DCs favour for Th2 immune response 
      development after Mhp exposure in vitro. Taken together, Mhp infection impairs 
      the immune function which allows the persistence of Mhp and cause predispose pigs 
      to secondary infections. The decline of DCs presentation ability is the reason 
      why dysfunction and persistence in Mhp infection. These findings are benefit for 
      exploring the pathogenic mechanisms of Mhp in pigs.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Shen, Yumeng
AU  - Shen Y
AD  - Veterinary College, Nanjing Agricultural University, Weigang 1, Nanjing, Jiangsu 
      210095, PR China.
FAU - Hu, Weiwei
AU  - Hu W
AD  - Veterinary College, Nanjing Agricultural University, Weigang 1, Nanjing, Jiangsu 
      210095, PR China.
FAU - Wei, Yanna
AU  - Wei Y
AD  - Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key 
      Laboratory of Veterinary Biological Engineering and Technology, Ministry of 
      Agriculture, National Center for Engineering Research of Veterinary Bio-Products, 
      Nanjing 210014, PR China.
FAU - Feng, Zhixin
AU  - Feng Z
AD  - Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key 
      Laboratory of Veterinary Biological Engineering and Technology, Ministry of 
      Agriculture, National Center for Engineering Research of Veterinary Bio-Products, 
      Nanjing 210014, PR China.
FAU - Yang, Qian
AU  - Yang Q
AD  - Veterinary College, Nanjing Agricultural University, Weigang 1, Nanjing, Jiangsu 
      210095, PR China. Electronic address: zxbyq@njau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20161117
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin A, Secretory)
SB  - IM
MH  - Animals
MH  - Cell Count
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Cytokines/genetics
MH  - Dendritic Cells/*immunology/*microbiology/pathology
MH  - Gene Expression Regulation/immunology
MH  - Host-Pathogen Interactions/*immunology
MH  - Immunoglobulin A, Secretory/metabolism
MH  - Macrophages/cytology
MH  - Mycoplasma hyopneumoniae/*immunology
MH  - Nasal Cavity/immunology/microbiology/pathology
MH  - Pneumonia of Swine, Mycoplasmal/*immunology/pathology
MH  - Specific Pathogen-Free Organisms
MH  - Swine
MH  - T-Lymphocytes/cytology/immunology
OTO - NOTNLM
OT  - Dendritic cells
OT  - Mycoplasma hyopneumoniae
OT  - Nasal cavity
EDAT- 2017/01/08 06:00
MHDA- 2017/03/09 06:00
CRDT- 2017/01/08 06:00
PHST- 2016/06/22 00:00 [received]
PHST- 2016/11/15 00:00 [revised]
PHST- 2016/11/16 00:00 [accepted]
PHST- 2017/01/08 06:00 [entrez]
PHST- 2017/01/08 06:00 [pubmed]
PHST- 2017/03/09 06:00 [medline]
AID - S0378-1135(16)30667-8 [pii]
AID - 10.1016/j.vetmic.2016.11.018 [doi]
PST - ppublish
SO  - Vet Microbiol. 2017 Jan;198:1-8. doi: 10.1016/j.vetmic.2016.11.018. Epub 2016 Nov 
      17.