PMID- 28063398
OWN - NLM
STAT- MEDLINE
DCOM- 20171211
LR  - 20190318
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 249
DP  - 2017 Mar
TI  - Brain-derived neurotrophic factor (BDNF) and oxidative stress in heroin-dependent 
      male patients undergoing methadone maintenance treatment.
PG  - 46-50
LID - S0165-1781(16)31097-6 [pii]
LID - 10.1016/j.psychres.2016.12.042 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) and oxidative stress may play a role in 
      patients with heroin dependence. The aim of this study was to investigate the 
      serum levels and activities of BDNF and oxidative stress markers, such as 
      superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), 
      thiobarbituric acid reactive substances (TBARS), protein carbonyl content (PCC), 
      and 8-hydroxy 2'-deoxyguanosine (8-OHdG), in heroin-dependent patients undergoing 
      methadone maintenance treatment (MMT). 60 heroin-dependent male MMT patients and 
      30 healthy males were recruited for this study. The serum BDNF and oxidative 
      stress markers of these subjects were measured with assay kits. Analyses of 
      covariance (ANCOVAs) with age and body mass index adjustments indicated that the 
      serum levels of BDNF in the MMT patients were significantly higher than those in 
      the healthy controls (F=5.169; p=0.026). However, there were no significant 
      differences between the heroin-dependent patients and the healthy controls in the 
      serum levels or activities of oxidative stress markers (p>0.05). In conclusion, 
      our results suggest that MMT increases BDNF levels in heroin-dependent patients, 
      and that patients undergoing MMT might be in a balanced state of reduced 
      oxidation.
CI  - Copyright (c) 2017 Elsevier Ireland Ltd. All rights reserved.
FAU - Tsai, Meng-Chang
AU  - Tsai MC
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan.
FAU - Huang, Tiao-Lai
AU  - Huang TL
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung 
      University College of Medicine, Kaohsiung, Taiwan. Electronic address: 
      a540520@adm.cgmh.org.tw.
LA  - eng
PT  - Journal Article
DEP - 20161227
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - UC6VBE7V1Z (Methadone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Heroin Dependence/*blood/drug therapy/*physiopathology
MH  - Humans
MH  - Male
MH  - Methadone/*therapeutic use
MH  - Middle Aged
MH  - Oxidation-Reduction/drug effects
MH  - Oxidative Stress/*physiology
OTO - NOTNLM
OT  - *BDNF
OT  - *Heroin
OT  - *Methadone
OT  - *Oxidative stress
OT  - *TBARS
EDAT- 2017/01/08 06:00
MHDA- 2017/12/12 06:00
CRDT- 2017/01/08 06:00
PHST- 2016/06/28 00:00 [received]
PHST- 2016/11/13 00:00 [revised]
PHST- 2016/12/27 00:00 [accepted]
PHST- 2017/01/08 06:00 [pubmed]
PHST- 2017/12/12 06:00 [medline]
PHST- 2017/01/08 06:00 [entrez]
AID - S0165-1781(16)31097-6 [pii]
AID - 10.1016/j.psychres.2016.12.042 [doi]
PST - ppublish
SO  - Psychiatry Res. 2017 Mar;249:46-50. doi: 10.1016/j.psychres.2016.12.042. Epub 
      2016 Dec 27.