PMID- 28064223
OWN - NLM
STAT- MEDLINE
DCOM- 20170425
LR  - 20181113
IS  - 1791-7549 (Electronic)
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 31
IP  - 1
DP  - 2017 Jan 2
TI  - Influence of Periostin on Synoviocytes in Knee Osteoarthritis.
PG  - 69-77
AB  - BACKGROUND: Periostin (POSTN) is a protein that binds to integrins to support 
      adhesion and migration of epithelial cells. Mice lacking this gene exhibit 
      cardiac valve disease as well as skeletal and dental defects. Recent studies 
      indicated that periostin is involved in the pathogenesis and progression of knee 
      osteoarthritis (OA). We investigated the influence of periostin and matrix 
      metalloproteinases (MMPs) on OA synoviocytes. MATERIALS AND METHODS: OA patients 
      were classified according to the Kellgren-Lawrence system and the levels of 
      periostin, interleukin (IL)-4, IL-13 and transforming growth factor-beta (TGFbeta) in 
      the synovial fluid were measured. MMPs or tissue inhibitor of MMPs (TIMPs) with 
      periostin in cultured cells were measured when periostin was added to 
      OA-associated synovial cells. Dexamethasone, a steroid medication which shows 
      immunosuppressive effects, was used to investigate the influence of the 
      downstream cascade. RESULTS: Periostin and IL-13 levels were up-regulated during 
      the progression of OA. MMP-2 and MMP-3 levels increased in a periostin 
      concentration-dependent manner. Increase in MMP-2 and MMP-3 levels was inhibited 
      by dexamethasone treatment. CONCLUSION: In vivo results herein indicate that 
      IL-13 may induce periostin production in OA. Furthermore, periostin may 
      facilitate MMP production in OA-associated synovial cells.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Tajika, Yutaro
AU  - Tajika Y
AD  - Department of Physiology, School of Medicine, Showa University, Tokyo, Japan.
FAU - Moue, Tatsuya
AU  - Moue T
AD  - Department of Physiology, School of Medicine, Showa University, Tokyo, Japan.
FAU - Ishikawa, Shintaro
AU  - Ishikawa S
AD  - Department of Physiology, School of Medicine, Showa University, Tokyo, Japan 
      s-ishikawa@med.showa-u.ac.jp.
FAU - Asano, Kazuhito
AU  - Asano K
AD  - Department of Physiology, School of Medicine, Showa University, Tokyo, Japan.
FAU - Okumo, Takayuki
AU  - Okumo T
AD  - Department of Physiology, School of Medicine, Showa University, Tokyo, Japan.
FAU - Takagi, Hiroshi
AU  - Takagi H
AD  - Department of Orthopaedic Surgery, Showa University Fujigaoka Hospital, Kanagawa, 
      Japan.
FAU - Hisamitsu, Tadashi
AU  - Hisamitsu T
AD  - Department of Physiology, School of Medicine, Showa University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
RN  - 0 (POSTN protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Biomarkers/*analysis
MH  - Cell Adhesion Molecules/genetics/*metabolism
MH  - Cells, Cultured
MH  - Cytokines/genetics/metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - Mice
MH  - Osteoarthritis, Knee/genetics/*metabolism/pathology
MH  - Real-Time Polymerase Chain Reaction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Synovial Fluid/chemistry
MH  - Synoviocytes/*metabolism/pathology
PMC - PMC5354150
OTO - NOTNLM
OT  - Dexamethasone
OT  - knee osteoarthritis
OT  - matrix metalloproteinase
OT  - periostin
EDAT- 2017/01/09 06:00
MHDA- 2017/04/26 06:00
PMCR- 2017/01/05
CRDT- 2017/01/09 06:00
PHST- 2016/11/04 00:00 [received]
PHST- 2016/11/18 00:00 [revised]
PHST- 2016/12/19 00:00 [accepted]
PHST- 2017/01/09 06:00 [entrez]
PHST- 2017/01/09 06:00 [pubmed]
PHST- 2017/04/26 06:00 [medline]
PHST- 2017/01/05 00:00 [pmc-release]
AID - 31/1/69 [pii]
AID - 10.21873/invivo.11027 [doi]
PST - ppublish
SO  - In Vivo. 2017 Jan 2;31(1):69-77. doi: 10.21873/invivo.11027.