PMID- 28065481
OWN - NLM
STAT- MEDLINE
DCOM- 20190724
LR  - 20190724
IS  - 1532-1983 (Electronic)
IS  - 0261-5614 (Linking)
VI  - 37
IP  - 1
DP  - 2018 Feb
TI  - Differences in the interaction between CETP Taq1B polymorphism and dietary fat 
      intake on lipid profile of normolipedemic and dyslipidemic patients with type 2 
      diabetes mellitus.
PG  - 270-275
LID - S0261-5614(16)31365-6 [pii]
LID - 10.1016/j.clnu.2016.12.024 [doi]
AB  - BACKGROUND & AIM: Dyslipidemia is one of the major complications in patients with 
      type 2 diabetes mellitus (T2DM). Dietary fat intake and genetic factors including 
      CETP Taq1B polymorphism could also affect lipid profile concentrations, in 
      particular HDL-c. We decided to study the frequency of this polymorphism and its 
      interaction with dietary fat intake on HDL-c concentration among Iranian T2DM 
      patients with and without dyslipidemia. METHODS: In this comparative study, serum 
      samples were collected from 55 patients with dyslipidemia and 129 patients 
      without dyslipidemia. Validated semi-quantitative FFQ was used for food 
      consumption data. CETP Taq1B polymorphism was studied by polymerase chain 
      reaction-restriction length polymorphism (PCR-RFLP). We used chi(2) and two-way 
      ANOVA tests for statistical analysis. RESULTS: The frequency of B1B1 genotype was 
      higher in patients with dyslipidemia (p = 0.01). There was no significant 
      relationship between CETP Taq1B polymorphism and lipid profile concentrations. In 
      patients without dyslipidemia, the interaction between the polymorphism and total 
      fat intake on HDL-c concentration as well as TG/HDL ratio was significant 
      (p = 0.02 and p = 0.009 respectively). This was more evident in B1B1 genotype. 
      Moreover, HDL-c concentration was significantly higher in B2B2 genotype with low 
      total fat intake. CONCLUSION: Higher total fat intake may affect the relationship 
      between CETP Taq1B polymorphism and HDL-c concentration in patients with 
      normolipidemic T2DM.
CI  - Copyright (c) 2016 Elsevier Ltd and European Society for Clinical Nutrition and 
      Metabolism. All rights reserved.
FAU - Kalantar, Zahra
AU  - Kalantar Z
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Eshraghian, Mohamad Reza
AU  - Eshraghian MR
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Sotoudeh, Gity
AU  - Sotoudeh G
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Djalali, Mahmoud
AU  - Djalali M
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Mansouri, Anahita
AU  - Mansouri A
AD  - Nutrition and Metabolic Diseases Center, Ahvaz Jundishapur University of Medical 
      Sciences, Ahvaz, Iran.
FAU - Alvandi, Ehsan
AU  - Alvandi E
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Javadi, Fatemeh
AU  - Javadi F
AD  - School of Nutritional Sciences and Dietetics, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Mahmoudi, Maryam
AU  - Mahmoudi M
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Koohdani, Fariba
AU  - Koohdani F
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Diabetic 
      Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran 
      University of Medical Sciences, Tehran, Iran. Electronic address: 
      fkoohdan@tums.ac.ir.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161231
PL  - England
TA  - Clin Nutr
JT  - Clinical nutrition (Edinburgh, Scotland)
JID - 8309603
RN  - 0 (CETP protein, human)
RN  - 0 (Cholesterol Ester Transfer Proteins)
RN  - 0 (Dietary Fats)
MH  - Cholesterol Ester Transfer Proteins/*genetics
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Diet/*statistics & numerical data
MH  - Dietary Fats/*analysis
MH  - *Dyslipidemias/epidemiology/genetics
MH  - Female
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic/genetics
OTO - NOTNLM
OT  - CETP
OT  - Dietary fat intake
OT  - HDL-c concentration
OT  - Lipid disorder
OT  - Taq1B polymorphism
EDAT- 2017/01/10 06:00
MHDA- 2019/07/25 06:00
CRDT- 2017/01/10 06:00
PHST- 2015/09/12 00:00 [received]
PHST- 2016/09/23 00:00 [revised]
PHST- 2016/12/28 00:00 [accepted]
PHST- 2017/01/10 06:00 [pubmed]
PHST- 2019/07/25 06:00 [medline]
PHST- 2017/01/10 06:00 [entrez]
AID - S0261-5614(16)31365-6 [pii]
AID - 10.1016/j.clnu.2016.12.024 [doi]
PST - ppublish
SO  - Clin Nutr. 2018 Feb;37(1):270-275. doi: 10.1016/j.clnu.2016.12.024. Epub 2016 Dec 
      31.