PMID- 28065503
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20191210
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 27
IP  - 3
DP  - 2017 Mar
TI  - 8-Hydroxy-2-deoxyguanosine levels and heart failure: A systematic review and 
      meta-analysis of the literature.
PG  - 201-208
LID - S0939-4753(16)30194-6 [pii]
LID - 10.1016/j.numecd.2016.10.009 [doi]
AB  - BACKGROUND AND AIMS: The generation of reactive oxygen species (ROS) plays an 
      important role in the etiology of several pathological conditions. High levels of 
      8-hydroxy-2-deoxyguanosine (8-OHdG), a biomarker of oxidative damage of DNA, have 
      been found in patients with heart failure (HF). We performed a meta-analysis of 
      the literature to investigate the association between 8-OHdG levels and HF. 
      METHODS AND RESULTS: A systematic search was performed in the PubMed, Web of 
      Science, Scopus, EMBASE databases and studies evaluating 8-OHdG levels in HF 
      patients and controls were included. Differences between cases and controls were 
      expressed as standard mean difference (SMD) or mean difference (MD) with 
      pertinent 95% confidence intervals (95%CI). Impact of clinical and demographic 
      features on effect size was assessed by meta-regression. Six studies (446 HF 
      patients and 140 controls) were included in the analysis. We found that HF 
      patients showed higher 8-OHdG levels than controls (SMD:0.89, 95%CI: 0.68, 1.10). 
      The difference was confirmed both in studies in which 8-OHdG levels were assessed 
      in urine (MD:6.28 ng/mg creatinine, 95%CI: 4.01, 8.56) and in blood samples 
      (MD:0.36 ng/ml, 95%CI: 0.04, 0.69). Interestingly, 8-OHdG levels progressively 
      increased for increasing New York Heart Association (NYHA) class. Meta-regression 
      models showed that none of clinical and demographic variables impacted on the 
      difference in 8-OHdG levels among HF patients and controls. CONCLUSIONS: 8-OHdG 
      levels are higher in HF patients HF than in controls, with a progressive increase 
      for increasing NYHA class. However, larger prospective studies are needed to test 
      8-OHdG as a biomarker of HF severity and progression.
CI  - Copyright (c) 2016 The Italian Society of Diabetology, the Italian Society for the 
      Study of Atherosclerosis, the Italian Society of Human Nutrition, and the 
      Department of Clinical Medicine and Surgery, Federico II University. Published by 
      Elsevier B.V. All rights reserved.
FAU - Di Minno, A
AU  - Di Minno A
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy. Electronic address: 
      alessandro.diminno@ccfm.it.
FAU - Turnu, L
AU  - Turnu L
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy.
FAU - Porro, B
AU  - Porro B
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy.
FAU - Squellerio, I
AU  - Squellerio I
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy.
FAU - Cavalca, V
AU  - Cavalca V
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze 
      Cliniche e di Comunita, Universita degli Studi di Milano, 20138 Milan, Italy.
FAU - Tremoli, E
AU  - Tremoli E
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze 
      Cliniche e di Comunita, Universita degli Studi di Milano, 20138 Milan, Italy.
FAU - Di Minno, M N D
AU  - Di Minno MN
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Advanced 
      Biomedical Sciences, Division of Cardiology, Federico II University, Naples, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20161120
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Biomarkers)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - G9481N71RO (Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Biomarkers/metabolism
MH  - Chi-Square Distribution
MH  - *DNA Damage
MH  - Deoxyguanosine/*analogs & derivatives/metabolism
MH  - Heart Failure/diagnosis/genetics/*metabolism/physiopathology
MH  - Humans
MH  - Myocardium/*metabolism
MH  - *Oxidative Stress
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Up-Regulation
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - 8-OHdG
OT  - Heart failure
OT  - Meta-analysis
OT  - Oxidative stress
EDAT- 2017/01/10 06:00
MHDA- 2017/09/07 06:00
CRDT- 2017/01/10 06:00
PHST- 2016/03/21 00:00 [received]
PHST- 2016/10/11 00:00 [revised]
PHST- 2016/10/28 00:00 [accepted]
PHST- 2017/01/10 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
PHST- 2017/01/10 06:00 [entrez]
AID - S0939-4753(16)30194-6 [pii]
AID - 10.1016/j.numecd.2016.10.009 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2017 Mar;27(3):201-208. doi: 
      10.1016/j.numecd.2016.10.009. Epub 2016 Nov 20.