PMID- 28065581
OWN - NLM
STAT- MEDLINE
DCOM- 20170814
LR  - 20181108
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 303
DP  - 2017 Feb 15
TI  - Nitric oxide synthase inhibitor, aminoguanidine reduces intracerebroventricular 
      colchicine induced neurodegeneration, memory impairments and changes of systemic 
      immune responses in rats.
PG  - 51-61
LID - S0165-5728(16)30450-7 [pii]
LID - 10.1016/j.jneuroim.2016.12.007 [doi]
AB  - Intracerebroventricular (i.c.v.) injection of colchicine induces 
      neurodegeneration, memory impairments and changes of some systemic immune 
      responses in rats. Though the role of cox 2 in these colchicine induced changes 
      have been evaluated, the influence of nitric oxide synthase (NOS) remains to be 
      studied. The present study was designed to assess the role of NOS on the i.c.v. 
      colchicine induced neurodegeneration, memory impairments and changes of some 
      systemic immune responses by inhibiting its activity with aminoguanidine. In the 
      present study the impairments of working and reference memories, 
      neurodegeneration (chromatolysis and plaque formation) and changes of 
      neuroinflammatory markers in the hippocampus (increased TNF alpha, IL 1beta, ROS and 
      nitrite) along with changes of serum inflammatory markers (TNF alpha, IL 1beta, ROS and 
      nitrite) and alteration of systemic immune responses (higher phagocytic activity 
      of blood WBC and splenic PMN, higher cytotoxicity and lower leukocyte adhesion 
      inhibition index of splenic MNC) were measured in the intracerebroventricular 
      colchicine injected rats (ICIR). Administration of aminoguanidine (p.o. 
      30/50mg/kg body weight) to ICIR resulted in recovery of neuroinflammation and 
      partial prevention of neurodegeneration which could be corroborated with the 
      partial recovery of memory impairments in this model. The recovery of serum 
      inflammatory markers and the systemic immune responses in ICIR was also observed 
      after administration of aminoguanidine. Therefore, the present study shows that 
      aminoguanidine can protect the colchicine induced neurodegeneration, memory 
      impairments, and changes of systemic immune systemic responses in ICIR by 
      inhibiting the iNOS.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Sil, Susmita
AU  - Sil S
AD  - Neurophysiology Laboratory, Department of Physiology, University College of 
      Science and Technology, University of Calcutta, 92, Acharya Prafulla Chandra 
      Road, Kolkata 700 009, West Bengal, India.
FAU - Ghosh, Tusharkanti
AU  - Ghosh T
AD  - Neurophysiology Laboratory, Department of Physiology, University College of 
      Science and Technology, University of Calcutta, 92, Acharya Prafulla Chandra 
      Road, Kolkata 700 009, West Bengal, India. Electronic address: 
      tusharkantighosh53@yahoo.in.
FAU - Ghosh, Rupsa
AU  - Ghosh R
AD  - Neurophysiology Laboratory, Department of Physiology, University College of 
      Science and Technology, University of Calcutta, 92, Acharya Prafulla Chandra 
      Road, Kolkata 700 009, West Bengal, India.
FAU - Gupta, Pritha
AU  - Gupta P
AD  - Neurophysiology Laboratory, Department of Physiology, University College of 
      Science and Technology, University of Calcutta, 92, Acharya Prafulla Chandra 
      Road, Kolkata 700 009, West Bengal, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161213
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Guanidines)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.13.39 (Nos2 protein, rat)
RN  - SCQ4EZQ113 (pimagedine)
RN  - SML2Y3J35T (Colchicine)
SB  - IM
MH  - Animals
MH  - Colchicine/administration & dosage/*toxicity
MH  - Enzyme Inhibitors/pharmacology/*therapeutic use
MH  - Guanidines/pharmacology/*therapeutic use
MH  - Hippocampus/drug effects/immunology
MH  - Injections, Intraventricular
MH  - Male
MH  - Memory Disorders/chemically induced/*drug therapy/immunology
MH  - Mice
MH  - Neurodegenerative Diseases/chemically induced/*drug therapy/immunology
MH  - Nitric Oxide Synthase Type II/*antagonists & inhibitors/immunology
MH  - Rats
OTO - NOTNLM
OT  - Aminoguanidine
OT  - Colchicine
OT  - Neurodegeneration
OT  - Neuroinflammation
OT  - Systemic immune responses
EDAT- 2017/01/10 06:00
MHDA- 2017/08/15 06:00
CRDT- 2017/01/10 06:00
PHST- 2016/04/26 00:00 [received]
PHST- 2016/11/23 00:00 [revised]
PHST- 2016/12/12 00:00 [accepted]
PHST- 2017/01/10 06:00 [pubmed]
PHST- 2017/08/15 06:00 [medline]
PHST- 2017/01/10 06:00 [entrez]
AID - S0165-5728(16)30450-7 [pii]
AID - 10.1016/j.jneuroim.2016.12.007 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2017 Feb 15;303:51-61. doi: 10.1016/j.jneuroim.2016.12.007. Epub 
      2016 Dec 13.