PMID- 28065595
OWN - NLM
STAT- MEDLINE
DCOM- 20180417
LR  - 20180417
IS  - 1878-3252 (Electronic)
IS  - 0946-672X (Linking)
VI  - 43
DP  - 2017 Sep
TI  - The influence of selenium status on body composition, oxidative DNA damage and 
      total antioxidant capacity in newly diagnosed type 2 diabetes mellitus: A 
      case-control study.
PG  - 106-112
LID - S0946-672X(16)30228-0 [pii]
LID - 10.1016/j.jtemb.2016.12.009 [doi]
AB  - Selenium is involved in the complex system of defense against oxidative stress in 
      diabetes through its biological function of selenoproteins and the antioxidant 
      enzyme. A case-control study was carried out to determine the association of 
      plasma selenium with oxidative stress and body composition status presented in 
      Type 2 Diabetes Mellitus (T2DM) patient and healthy control. This study involved 
      82 newly diagnosed T2DM patients and 82 healthy controls. Plasma selenium status 
      was determined with Graphite Furnace Atomic Absorption Spectrometry. Body Mass 
      Index, total body fat and visceral fat was assessed for body composition using 
      Body Composition Analyzer (TANITA). Oxidative DNA damage and total antioxidant 
      capacity were determined for oxidative stress biomarker status. In age, gender 
      and BMI adjustment, no significant difference of plasma selenium level between 
      T2DM and healthy controls was observed. There was as a significant difference of 
      Oxidative DNA damage and total antioxidant capacity between T2DM patients and 
      healthy controls with tail DNA% 20.62 [95% CI: 19.71,21.49] (T2DM), 17.67 [95% 
      CI: 16.87,18.56] (control); log tail moment 0.41[95% CI: 0.30,0.52] (T2DM), 
      0.41[95% CI: 0.30,0.52] (control); total antioxidant capacity 0.56 [95% CI: 
      0.54,0.58] (T2DM), 0.60 [95% CI: 0.57,0.62] (control). Waist circumference, BMI, 
      visceral fat, body fat and oxidative DNA damage in the T2DM group were 
      significantly lower in the first plasma selenium tertile (38.65-80.90mug/L) 
      compared to the second (80.91-98.20mug/L) and the third selenium tertiles 
      (98.21-158.20mug/L). A similar trend, but not statistically significant, was 
      observed in the control group.
CI  - Copyright (c) 2016 Elsevier GmbH. All rights reserved.
FAU - Othman, Fatimah Binti
AU  - Othman FB
AD  - Centre of Nutrition Epidemiology Research, Institute For Public Health, Ministry 
      of Health, Jalan Bangsar, 50590 Kuala Lumpur, Malaysia; Nutrition and Dietetics 
      Programme, School of Health Sciences, Universiti Sains Malaysia, Kelantan, 
      Malaysia. Electronic address: fatimah.oth@moh.gov.my.
FAU - Mohamed, Hamid Jan Bin Jan
AU  - Mohamed HJBJ
AD  - Nutrition and Dietetics Programme, School of Health Sciences, Universiti Sains 
      Malaysia, Kelantan, Malaysia. Electronic address: hamidjan@usm.my.
FAU - Sirajudeen, K N S
AU  - Sirajudeen KNS
AD  - Department of Chemical Pathology, School of Medical Sciences, Health Campus, 
      Universiti Sains Malaysia, Kelantan, Malaysia. Electronic address: 
      sirajuden@usm.my.
FAU - Noh, Mohd Fairulnizal B Md
AU  - Noh MFBM
AD  - Cardiovascular, Diabetes and Nutrition Research Centre, Institute for Medical 
      Research, Kuala Lumpur, Malaysia. Electronic address: fairul@imr.gov.my.
FAU - Rajab, Nor Fadilah
AU  - Rajab NF
AD  - Biomedical Science Program, School of Diagnostic and Applied Health Sciences, 
      Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, 
      Malaysia. Electronic address: nfadilah@ukm.edu.my.
LA  - eng
PT  - Journal Article
DEP - 20161229
PL  - Germany
TA  - J Trace Elem Med Biol
JT  - Journal of trace elements in medicine and biology : organ of the Society for 
      Minerals and Trace Elements (GMS)
JID - 9508274
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Adult
MH  - Antioxidants/*metabolism
MH  - Blood Glucose/metabolism
MH  - Body Composition/genetics/physiology
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - DNA Damage/genetics
MH  - Diabetes Mellitus, Type 2/*blood/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - Oxidative Stress/physiology
MH  - Selenium/*metabolism
MH  - Waist Circumference
OTO - NOTNLM
OT  - Body composition
OT  - Graphite Furnace Atomic Absorption Spectrometry
OT  - Oxidative DNA damage
OT  - Selenium
OT  - Total antioxidant capacity
OT  - Type 2 diabetes mellitus
EDAT- 2017/01/10 06:00
MHDA- 2018/04/18 06:00
CRDT- 2017/01/10 06:00
PHST- 2016/08/24 00:00 [received]
PHST- 2016/12/21 00:00 [revised]
PHST- 2016/12/21 00:00 [accepted]
PHST- 2017/01/10 06:00 [pubmed]
PHST- 2018/04/18 06:00 [medline]
PHST- 2017/01/10 06:00 [entrez]
AID - S0946-672X(16)30228-0 [pii]
AID - 10.1016/j.jtemb.2016.12.009 [doi]
PST - ppublish
SO  - J Trace Elem Med Biol. 2017 Sep;43:106-112. doi: 10.1016/j.jtemb.2016.12.009. 
      Epub 2016 Dec 29.