PMID- 28065711
OWN - NLM
STAT- MEDLINE
DCOM- 20170925
LR  - 20200306
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Print)
IS  - 0018-506X (Linking)
VI  - 89
DP  - 2017 Mar
TI  - A comparison of the effects of male pheromone priming and optogenetic inhibition 
      of accessory olfactory bulb forebrain inputs on the sexual behavior of estrous 
      female mice.
PG  - 104-112
LID - S0018-506X(16)30421-4 [pii]
LID - 10.1016/j.yhbeh.2016.12.011 [doi]
AB  - Previous research has shown that repeated testing with a stimulus male is 
      required for ovariectomized, hormone-primed female mice to become sexually 
      receptive (show maximal lordosis quotients; LQs) and that drug-induced, 
      epigenetic enhancement of estradiol receptor function accelerated the improvement 
      in LQs otherwise shown by estrous females with repeated testing. We asked whether 
      pre-exposure to male pheromones ('pheromone priming') would also accelerate the 
      improvement in LQs with repeated tests and whether optogenetic inhibition of 
      accessory olfactory bulb (AOB) projection neurons could inhibit lordosis in 
      sexually experienced estrous female mice. In Experiment 1, repeated priming with 
      soiled male bedding failed to accelerate the progressive improvement in LQs shown 
      by estrous female mice across 5 tests, although the duration of each lordosis 
      response and females' investigation of male body parts during the first test was 
      augmented by such priming. In Experiment 2, acute optogenetic inhibition of AOB 
      inputs to the forebrain during freely moving behavioral tests significantly 
      reduced LQs, suggesting that continued AOB signaling to the forebrain during 
      mating is required for maximal lordotic responsiveness even in sexually 
      experienced females. Our results also suggest that pheromonal stimulation, by 
      itself, cannot substitute for the full complement of sensory stimulation received 
      by estrous females from mounting males that normally leads to the progressive 
      improvement in their LQs with repeated testing.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - McCarthy, Elizabeth A
AU  - McCarthy EA
AD  - Department of Biology, Boston University, Boston, MA 02215, United States.
FAU - Kunkhyen, Tenzin
AU  - Kunkhyen T
AD  - Department of Psychological and Brain Sciences, Boston University, Boston, MA 
      02215, United States.
FAU - Korzan, Wayne J
AU  - Korzan WJ
AD  - Department of Psychological and Brain Sciences, Boston University, Boston, MA 
      02215, United States.
FAU - Naik, Ajay
AU  - Naik A
AD  - Department of Biology, Boston University, Boston, MA 02215, United States.
FAU - Maqsudlu, Arman
AU  - Maqsudlu A
AD  - Department of Biology, Boston University, Boston, MA 02215, United States.
FAU - Cherry, James A
AU  - Cherry JA
AD  - Department of Psychological and Brain Sciences, Boston University, Boston, MA 
      02215, United States.
FAU - Baum, Michael J
AU  - Baum MJ
AD  - Department of Biology, Boston University, Boston, MA 02215, United States.
LA  - eng
GR  - R01 DC008962/DC/NIDCD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
DEP - 20170105
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Pheromones)
SB  - IM
MH  - Animals
MH  - Estrus/drug effects/*physiology
MH  - Female
MH  - Male
MH  - Mice
MH  - Neural Inhibition/*physiology
MH  - Olfactory Bulb/*physiology
MH  - *Optogenetics
MH  - Pheromones/*physiology
MH  - *Posture
MH  - Sexual Behavior, Animal/*physiology
PMC - PMC5359026
MID - NIHMS845345
OTO - NOTNLM
OT  - Lordosis
OT  - Odor investigation
OT  - Optogenetics
OT  - Pheromone
OT  - Sexual behavior
EDAT- 2017/01/10 06:00
MHDA- 2017/09/26 06:00
PMCR- 2018/03/01
CRDT- 2017/01/10 06:00
PHST- 2016/09/13 00:00 [received]
PHST- 2016/12/07 00:00 [revised]
PHST- 2016/12/20 00:00 [accepted]
PHST- 2017/01/10 06:00 [pubmed]
PHST- 2017/09/26 06:00 [medline]
PHST- 2017/01/10 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - S0018-506X(16)30421-4 [pii]
AID - 10.1016/j.yhbeh.2016.12.011 [doi]
PST - ppublish
SO  - Horm Behav. 2017 Mar;89:104-112. doi: 10.1016/j.yhbeh.2016.12.011. Epub 2017 Jan 
      5.