PMID- 28066203
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 10
DP  - 2016
TI  - Association of Increased Serum ACE Activity with Logical Memory Ability in Type 2 
      Diabetic Patients with Mild Cognitive Impairment.
PG  - 239
LID - 10.3389/fnbeh.2016.00239 [doi]
LID - 239
AB  - Background: Angiotensin-converting enzyme (ACE) is involved in the chronic 
      complications of type 2 diabetes mellitus (T2DM) and Alzheimer's disease. This 
      study aimed to assess the pathogenetic roles of ACE and the genetic 
      predisposition of its insertion/deletion (I/D) polymorphism in mild cognitive 
      impairment (MCI) among T2DM patients. Methods: A total of 210 T2DM patients were 
      enrolled. Among these patients, 116 satisfied the MCI diagnostic criteria and 94 
      exhibited healthy cognition. The cognitive functions of the patients were 
      extensively assessed. The serum level and activity of ACE were measured via 
      enzyme-linked immunosorbent assay and ultraviolet spectrophotography. The 
      single-nucleotide polymorphisms of I/D gene of ACE were analyzed. Results: The 
      serum level and activity of ACE in diabetic MCI patients (p = 0.022 and p = 
      0.008, respectively) were both significantly higher than those in the healthy 
      controls. A significant negative correlation was found between their ACE activity 
      and logical memory test score (LMT) (p = 0.002). Multiple stepwise regression 
      iterated the negative correlation between ACE activity and LMT score (p = 0.035). 
      Although no significant difference was found in the genotype or allele 
      distribution of ACE I/D polymorphism between the groups, the serum levels and 
      activity of ACE were higher in the DD group than in the ID and II groups (p < 
      0.05). Conclusions: Serum ACE activity could better predict logical memory in 
      T2DM patients than ACE level. Further investigations on a large population size 
      are necessary to test whether the D-allele of the ACE gene polymorphism is 
      susceptible to memory deterioration.
FAU - Tian, Sai
AU  - Tian S
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast 
      UniversityNanjing, China; Medical School of Southeast UniversityNanjing, China.
FAU - Han, Jing
AU  - Han J
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University 
      Nanjing, China.
FAU - Huang, Rong
AU  - Huang R
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University 
      Nanjing, China.
FAU - Xia, Wenqing
AU  - Xia W
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University 
      Nanjing, China.
FAU - Sun, Jie
AU  - Sun J
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University 
      Nanjing, China.
FAU - Cai, Rongrong
AU  - Cai R
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University 
      Nanjing, China.
FAU - Dong, Xue
AU  - Dong X
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University 
      Nanjing, China.
FAU - Shen, Yanjue
AU  - Shen Y
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University 
      Nanjing, China.
FAU - Wang, Shaohua
AU  - Wang S
AD  - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University 
      Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20161223
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC5179508
OTO - NOTNLM
OT  - angiotensin-converting enzyme
OT  - memory
OT  - mild cognitive impairment
OT  - polymorphism
OT  - type 2 diabetes mellitus
EDAT- 2017/01/10 06:00
MHDA- 2017/01/10 06:01
PMCR- 2016/01/01
CRDT- 2017/01/10 06:00
PHST- 2016/08/26 00:00 [received]
PHST- 2016/12/08 00:00 [accepted]
PHST- 2017/01/10 06:00 [entrez]
PHST- 2017/01/10 06:00 [pubmed]
PHST- 2017/01/10 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2016.00239 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2016 Dec 23;10:239. doi: 10.3389/fnbeh.2016.00239. 
      eCollection 2016.