PMID- 28066418
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 7
DP  - 2016
TI  - Shared HLA Class I and II Alleles and Clonally Restricted Public and Private 
      Brain-Infiltrating alphabeta T Cells in a Cohort of Rasmussen Encephalitis Surgery 
      Patients.
PG  - 608
LID - 10.3389/fimmu.2016.00608 [doi]
LID - 608
AB  - Rasmussen encephalitis (RE) is a rare pediatric neuroinflammatory disease 
      characterized by intractable seizures and unilateral brain atrophy. T cell 
      infiltrates in affected brain tissue and the presence of circulating 
      autoantibodies in some RE patients have indicated that RE may be an autoimmune 
      disease. The strongest genetic links to autoimmunity reside in the MHC locus, 
      therefore, we determined the human leukocyte antigen (HLA) class I and class II 
      alleles carried by a cohort of 24 RE surgery cases by targeted in-depth genomic 
      sequencing. Compared with a reference population the allelic frequency of three 
      alleles, DQA1*04:01:01, DQB1*04:02:01, and HLA-C*07:02:01:01 indicated that they 
      might confer susceptibility to the disease. It has been reported that HLA-C*07:02 
      is a risk factor for Graves disease. Further, eight patients in the study cohort 
      carried HLA-A*03:01:01:01, which has been linked to susceptibility to multiple 
      sclerosis. Four patients carried a combination of three HLA class II alleles that 
      has been linked to type 1 diabetes 
      (DQA1*05:01:01:01~DQB1*02:01:01~DRB1*03:01:01:01), and five patients carried a 
      combination of HLA class II alleles that has been linked to the risk of 
      contracting multiple sclerosis (DQA1*01:02:01:01, DQB1*06:02:01, 
      DRB1*15:01:01:01). We also analyzed the diversity of alphabeta T cells in brain and 
      blood specimens from 14 of these RE surgery cases by sequencing the third 
      complementarity regions (CDR3s) of rearranged T cell receptor beta genes. A total of 
      31 unique CDR3 sequences accounted for the top 5% of all CDR3 sequences in the 14 
      brain specimens. Thirteen of these sequences were found in sequencing data from 
      healthy blood donors; the remaining 18 sequences were patient specific. These 
      observations provide evidence for the clonal expansion of public and private T 
      cells in the brain, which might be influenced by the RE patient's HLA haplotype.
FAU - Dandekar, Sugandha
AU  - Dandekar S
AD  - Department of Medicine, David Geffen School of Medicine at the University of 
      California Los Angeles , Los Angeles, CA , USA.
FAU - Wijesuriya, Hemani
AU  - Wijesuriya H
AD  - Pathology and Laboratory Medicine, David Geffen School of Medicine at the 
      University of California Los Angeles , Los Angeles, CA , USA.
FAU - Geiger, Tim
AU  - Geiger T
AD  - Adaptive Biotechnologies Inc. , Seattle, WA , USA.
FAU - Hamm, David
AU  - Hamm D
AD  - Adaptive Biotechnologies Inc. , Seattle, WA , USA.
FAU - Mathern, Gary W
AU  - Mathern GW
AD  - Department of Neurosurgery, David Geffen School of Medicine at the University of 
      California Los Angeles, Los Angeles, CA, USA; Intellectual and Developmental 
      Disabilities Research Center, David Geffen School of Medicine at the University 
      of California Los Angeles, Los Angeles, CA, USA; Brain Research Institute, David 
      Geffen School of Medicine at the University of California Los Angeles, Los 
      Angeles, CA, USA; Mattel Children's Hospital, Los Angeles, CA, USA.
FAU - Owens, Geoffrey C
AU  - Owens GC
AD  - Department of Neurosurgery, David Geffen School of Medicine at the University of 
      California Los Angeles , Los Angeles, CA , USA.
LA  - eng
GR  - R01 NS083823/NS/NINDS NIH HHS/United States
GR  - U01 MH108898/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20161219
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC5165278
OTO - NOTNLM
OT  - Rasmussen encephalitis
OT  - T cell receptor
OT  - autoimmunity
OT  - epilepsy
OT  - human leukocyte antigen
EDAT- 2017/01/10 06:00
MHDA- 2017/01/10 06:01
PMCR- 2016/01/01
CRDT- 2017/01/10 06:00
PHST- 2016/09/20 00:00 [received]
PHST- 2016/12/01 00:00 [accepted]
PHST- 2017/01/10 06:00 [entrez]
PHST- 2017/01/10 06:00 [pubmed]
PHST- 2017/01/10 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2016.00608 [doi]
PST - epublish
SO  - Front Immunol. 2016 Dec 19;7:608. doi: 10.3389/fimmu.2016.00608. eCollection 
      2016.