PMID- 28066696
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2193-1801 (Print)
IS  - 2193-1801 (Electronic)
IS  - 2193-1801 (Linking)
VI  - 5
IP  - 1
DP  - 2016
TI  - Correlations of microRNA-124a and microRNA-30d with clinicopathological features 
      of breast cancer patients with type 2 diabetes mellitus.
PG  - 2107
LID - 10.1186/s40064-016-3786-9 [doi]
LID - 2107
AB  - This study intends to investigate the correlations of miR-124a and miR-30d with 
      clinicopathological features of breast cancer (BC) patients with type 2 diabetes 
      mellitus (T2DM). A total of 72 BC patients with T2DM (diabetic group) and 144 BC 
      patients without T2DM (non-diabetic group) were enrolled in this study. Blood 
      glucose was detected by glucose oxidase methods. Glycosylated hemoglobin (HbA1c) 
      was measured by high performance liquid chromatography. Fasting insulin (FIns) 
      was measured by chemiluminescent microparticle immunoassay. Automatic biochemical 
      analyzer was used to detect triglyceride, total cholesterol (TC), high-density 
      lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). 
      Estradiol (E(2)) was detected by radioimmunoassay. Homeostasis model assessment 
      was applied to assess the insulin resistance (HOMA-IR) and beta-cell insulin 
      secretion (HOMA-IS). The expressions of miR124a and miR-30d were measured by 
      quantitative real-time polymerase chain reaction (qRT-PCR). There were 
      significant differences in age, the ratio of menopause, body mass index (BMI), 
      HDL-C, TC, 2-h plasma glucose (2hPG), FIns, HbA1c, HOMA-IS and HOMA-IR between 
      the diabetic and non-diabetic groups. The diabetic group had higher incidence of 
      lymph node metastasis than non-diabetic group. The miR-124a expression was 
      down-regulated while the miR-30d expression was up-regulated in BC patients with 
      T2DM. The correlation analysis showed that miR-124a expression was positively 
      correlated with HDL-C, while it was negatively correlated with age, HbA1c, LDL-C 
      and E(2). However, the miR-30d expression was negatively correlated with HDL-C 
      but positively correlated with age, HbA1c, LDL-C and E(2). In conclusion, 
      miR-124a and miR-30d may be correlated with clinicopathological features of BC 
      patients with T2DM. The miR-124a and miR-30d could serve as novel biomarkers for 
      early diagnosis of BC in patients with T2DM.
FAU - Han, Yu-Ling
AU  - Han YL
AD  - Department of Breast and Thyroid Surgery, Linyi People's Hospital, Linyi, 276000 
      People's Republic of China.
FAU - Cao, Xian-E
AU  - Cao XE
AD  - Department of Geriatrics, Linyi People's Hospital, North Park Road, 200 Meters 
      East of Municipal Party School, Linyi, 276000 Shandong Province People's Republic 
      of China.
FAU - Wang, Ju-Xun
AU  - Wang JX
AD  - Linyi City Family Planning Management Station, Linyi, 276000 People's Republic of 
      China.
FAU - Dong, Chun-Ling
AU  - Dong CL
AD  - Department of Nurse, Linyi People's Hospital, Linyi, 276000 People's Republic of 
      China.
FAU - Chen, Hong-Tao
AU  - Chen HT
AD  - Department of Rheumatism, Linyi People's Hospital, Linyi, 276000 People's 
      Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20161222
PL  - Switzerland
TA  - Springerplus
JT  - SpringerPlus
JID - 101597967
PMC - PMC5179477
OTO - NOTNLM
OT  - Breast cancer
OT  - Clinicopathological features
OT  - MicroRNA-124a
OT  - MicroRNA-30d
OT  - Type 2 diabetes mellitus
EDAT- 2017/01/10 06:00
MHDA- 2017/01/10 06:01
PMCR- 2016/12/22
CRDT- 2017/01/10 06:00
PHST- 2016/04/26 00:00 [received]
PHST- 2016/12/09 00:00 [accepted]
PHST- 2017/01/10 06:00 [entrez]
PHST- 2017/01/10 06:00 [pubmed]
PHST- 2017/01/10 06:01 [medline]
PHST- 2016/12/22 00:00 [pmc-release]
AID - 3786 [pii]
AID - 10.1186/s40064-016-3786-9 [doi]
PST - epublish
SO  - Springerplus. 2016 Dec 22;5(1):2107. doi: 10.1186/s40064-016-3786-9. eCollection 
      2016.