PMID- 28068297
OWN - NLM
STAT- MEDLINE
DCOM- 20170911
LR  - 20181202
IS  - 1752-7163 (Electronic)
IS  - 1752-7155 (Linking)
VI  - 11
IP  - 1
DP  - 2017 Jan 9
TI  - Fatty acid derivative, chemokine, and cytokine profiles in exhaled breath 
      condensates can differentiate adult and children paucibacillary tuberculosis 
      patients.
PG  - 016003
LID - 10.1088/1752-7163/11/1/016003 [doi]
AB  - The anti-mycobacterial immune response in adults and children with tuberculosis 
      (TB), as well as the response in bacteriologically positive and negative 
      patients, is different. However, knowledge of the immunological events occurring 
      in the lungs in these clinical situations remains scarce. Exhaled breath 
      condensate (EBC) samples may be useful for studying the inflammatory environment 
      of the lower airways in TB patients. The fatty acid, cytokine, and chemokine 
      profiles in EBC from healthy adults; smear-positive and smear-negative adult 
      patients; and healthy, asthmatic, and TB children were determined using gas 
      chromatography and LUMINEX, respectively. Unsaturated fatty acids, particularly 
      oleate, were increased in TB adults and children compared with healthy 
      individuals. Elevated levels of IL-17 were characteristic of paucibacillary 
      patients (adults and children), whereas elevated MCP-1 (monocyte chemotactic 
      protein-1) levels were characteristic of adult patients (smear-positive and 
      smear-negative). The levels of all of the molecules were comparable to the 
      controls after anti-TB treatment, suggesting that changes in the levels of the 
      molecules detected in the EBC samples were the result of the active pulmonary TB. 
      EBC samples may be an important tool for the detection of potential early 
      biomarkers in the different clinical manifestations of pulmonary TB and a useful 
      tool for the diagnosis of TB, particularly in children.
FAU - Mosquera-Restrepo, Sergio Fabian
AU  - Mosquera-Restrepo SF
AD  - Grupo de Inmunologia Celular e Inmunogenetica, Facultad de Medicina, Universidad 
      de Antioquia UdeA, Calle 70 No 52-21, Medellin, Colombia.
FAU - Caro, Ana Cecilia
AU  - Caro AC
FAU - Garcia, Luis F
AU  - Garcia LF
FAU - Pelaez-Jaramillo, Carlos Alberto
AU  - Pelaez-Jaramillo CA
FAU - Rojas, Mauricio
AU  - Rojas M
LA  - eng
PT  - Journal Article
DEP - 20170109
PL  - England
TA  - J Breath Res
JT  - Journal of breath research
JID - 101463871
RN  - 0 (Biomarkers)
RN  - 0 (Chemokines)
RN  - 0 (Esters)
RN  - 0 (Fatty Acids)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers/analysis
MH  - Breath Tests/*methods
MH  - Case-Control Studies
MH  - Chemokines/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Diagnosis, Differential
MH  - Discriminant Analysis
MH  - Esters/analysis
MH  - *Exhalation/physiology
MH  - Fatty Acids/*analysis
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Tuberculosis/*diagnosis/drug therapy
MH  - Young Adult
EDAT- 2017/01/10 06:00
MHDA- 2017/09/12 06:00
CRDT- 2017/01/10 06:00
PHST- 2017/01/10 06:00 [entrez]
PHST- 2017/01/10 06:00 [pubmed]
PHST- 2017/09/12 06:00 [medline]
AID - 10.1088/1752-7163/11/1/016003 [doi]
PST - epublish
SO  - J Breath Res. 2017 Jan 9;11(1):016003. doi: 10.1088/1752-7163/11/1/016003.