PMID- 28069291
OWN - NLM
STAT- MEDLINE
DCOM- 20180403
LR  - 20210119
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Print)
IS  - 0378-1135 (Linking)
VI  - 209
DP  - 2017 Sep
TI  - Antagonizing cytokine-mediated JAK-STAT signaling by porcine reproductive and 
      respiratory syndrome virus.
PG  - 57-65
LID - S0378-1135(16)30446-1 [pii]
LID - 10.1016/j.vetmic.2016.12.036 [doi]
AB  - Janus kinase (JAK)-signal transducer and activator of transcription (STAT) 
      signaling pathway is activated by myriad cytokines, which are involved in 
      regulation of cell growth, proliferation, differentiation, apoptosis, 
      angiogenesis, immunity and inflammatory response. Because of its significance in 
      immune response, JAK-STAT pathway is often targeted by pathogens, including 
      porcine reproductive and respiratory syndrome virus (PRRSV). PRRSV causes 
      reproductive failure in sows and respiratory disease in pigs of all ages. A 
      typical feature of the immune response to PRRSV infection in pigs is delayed 
      production and low titer of virus neutralizing antibodies, and weak cell-mediated 
      immune response. One of the possible reasons for the weak protective immune 
      response is that PRRSV interferes with cytokine-mediated JAK-STAT signaling. 
      PRRSV inhibits interferon-activated JAK-STAT signaling by blocking nuclear 
      translocation of STAT1 and STAT2. The mechanism is that PRRSV non-structural 
      protein 1beta (nsp1beta) induces degradation of karyopherin alpha1 (KPNA1), a critical 
      adaptor in nucleo-cytoplasmic transport. PRRSV also antagonizes IL6-activated 
      JAK-STAT3 signaling via inducing degradation of STAT3. In this review, we briefly 
      introduce JAK-STAT signaling, summarize the PRRSV interference with it, and 
      provide perspective on the perturbation in the context of PRRSV-elicited immune 
      response.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Yang, Liping
AU  - Yang L
AD  - Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland 
      Pathogen Research Institute, University of Maryland, College Park, MD, USA.
FAU - Zhang, Yan-Jin
AU  - Zhang YJ
AD  - Molecular Virology Laboratory, VA-MD College of Veterinary Medicine and Maryland 
      Pathogen Research Institute, University of Maryland, College Park, MD, USA. 
      Electronic address: zhangyj@umd.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161230
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Cytokines)
RN  - 0 (STAT Transcription Factors)
RN  - EC 2.7.10.2 (Janus Kinases)
SB  - IM
MH  - Animals
MH  - Cytokines/*metabolism
MH  - Janus Kinases/*metabolism
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/physiopathology
MH  - Porcine respiratory and reproductive syndrome virus/*physiology
MH  - STAT Transcription Factors/*metabolism
MH  - *Signal Transduction
MH  - Swine
PMC - PMC7117332
OTO - NOTNLM
OT  - Innate immunity
OT  - JAK-STAT signaling
OT  - JAKs
OT  - PRRSV
OT  - STATs
EDAT- 2017/01/11 06:00
MHDA- 2018/04/04 06:00
PMCR- 2016/12/30
CRDT- 2017/01/11 06:00
PHST- 2016/10/05 00:00 [received]
PHST- 2016/11/22 00:00 [revised]
PHST- 2016/12/27 00:00 [accepted]
PHST- 2017/01/11 06:00 [pubmed]
PHST- 2018/04/04 06:00 [medline]
PHST- 2017/01/11 06:00 [entrez]
PHST- 2016/12/30 00:00 [pmc-release]
AID - S0378-1135(16)30446-1 [pii]
AID - 10.1016/j.vetmic.2016.12.036 [doi]
PST - ppublish
SO  - Vet Microbiol. 2017 Sep;209:57-65. doi: 10.1016/j.vetmic.2016.12.036. Epub 2016 
      Dec 30.