PMID- 2806935 OWN - NLM STAT- MEDLINE DCOM- 19891205 LR - 20190903 IS - 0721-832X (Print) IS - 0721-832X (Linking) VI - 227 IP - 5 DP - 1989 TI - Nonspecific immunoglobulin E in aqueous humor: evaluation in uveitis. PG - 489-93 AB - The levels of immunoglobulin E (IgE) in aqueous humor (AH) and serum were determined in 74 uveitis patients and 13 control patients with senile cataract. Uveitis patients' levels ranged from less than 0.06 to 460 IU/ml according to the paper radioimmunosorbent test (PRIST; limit of sensitivity, 0.06 IU/ml). Only one control patient had an AH level higher than the sensitivity limit (0.08 IU/ml). Of the five patients with the highest levels in the AH, four had toxocaral retinitis. The ratio of AH/serum to IgE normalized to the albumin concentration was calculated in 25 uveitis patients and was greater than 0.60 in 13 cases, indicating a possible intraocular IgE synthesis. FAU - Hamel, C P AU - Hamel CP AD - Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892. FAU - De Luca, H AU - De Luca H FAU - Billotte, C AU - Billotte C FAU - Offret, H AU - Offret H FAU - Bloch-Michel, E AU - Bloch-Michel E LA - eng PT - Journal Article PL - Germany TA - Graefes Arch Clin Exp Ophthalmol JT - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JID - 8205248 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Adolescent MH - Aqueous Humor/*immunology MH - Child MH - Female MH - Humans MH - Immunoglobulin E/*biosynthesis MH - Male MH - Radioimmunosorbent Test MH - Toxocariasis/complications/immunology MH - Uveitis/etiology/*immunology EDAT- 1989/01/01 00:00 MHDA- 1989/01/01 00:01 CRDT- 1989/01/01 00:00 PHST- 1989/01/01 00:00 [pubmed] PHST- 1989/01/01 00:01 [medline] PHST- 1989/01/01 00:00 [entrez] AID - 10.1007/BF02172904 [doi] PST - ppublish SO - Graefes Arch Clin Exp Ophthalmol. 1989;227(5):489-93. doi: 10.1007/BF02172904.