PMID- 28070481
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2213-0071 (Print)
IS  - 2213-0071 (Electronic)
IS  - 2213-0071 (Linking)
VI  - 20
DP  - 2017
TI  - Lung adenocarcinoma and adrenocortical carcinoma in a patient with multiple 
      endocrine neoplasia type 1.
PG  - 77-81
LID - 10.1016/j.rmcr.2016.12.002 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder 
      caused by heterozygous germline mutations in the tumor suppressor gene MEN1, 
      which encodes a nuclear protein, menin. MEN1 is characterized by the combined 
      occurrence of tumors involving the pituitary gland, pancreatic islets, and 
      parathyroid glands. Additionally, patients with MEN1 often exhibit adrenal 
      tumors. Although most MEN1-associated tumors are benign, malignant lesions 
      arising in these endocrine organs have been reported. Additionally, malignant 
      diseases of non-endocrine organs concomitant with MEN1 have also been reported. 
      Here, we report a rare case of a MEN1 patient who exhibited adrenocortical 
      carcinoma (ACC) and lung adenocarcinoma (LAC). A 53-year-old Japanese woman was 
      diagnosed with genetically proven MEN1 that initially manifested as parathyroid, 
      pancreatic, and adrenal tumors. During the course of the disease, she developed 
      LAC harboring the epidermal growth factor receptor gene mutations and 
      cortisol-secreting ACC. Both tumors were surgically resected. The tumor cells 
      were immunohistochemically negative for menin. Studies have suggested a causative 
      link between MEN1 gene mutations and ACC, and menin expression may decrease in 
      MEN1-related ACCs. In contrast, there are few reports suggesting a specific role 
      of MEN1 gene mutations in LAC. Menin is often inactivated in the LACs of patients 
      without MEN1. Thus, our patient's ACC probably occurred as part of MEN1, whereas 
      the latter had no evident etiological association with her LAC. This case 
      demonstrates the need for physicians to consider the potential development of 
      malignant diseases originating from both endocrine and non-endocrine organs in 
      MEN1 patients.
FAU - Ohara, Nobumasa
AU  - Ohara N
AD  - Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Niigata, 
      Japan; Department of Endocrinology and Metabolism, Uonuma Institute of Community 
      Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan.
FAU - Kaneko, Masanori
AU  - Kaneko M
AD  - Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Niigata, 
      Japan.
FAU - Ikeda, Masahiro
AU  - Ikeda M
AD  - Department of Urology, Nagaoka Red Cross Hospital, Niigata, Japan.
FAU - Ishizaki, Fumio
AU  - Ishizaki F
AD  - Department of Urology, Nagaoka Red Cross Hospital, Niigata, Japan.
FAU - Suzuki, Kazuya
AU  - Suzuki K
AD  - Department of Urology, Nagaoka Red Cross Hospital, Niigata, Japan.
FAU - Maruyama, Ryo
AU  - Maruyama R
AD  - Department of Urology, Nagaoka Red Cross Hospital, Niigata, Japan.
FAU - Komeyama, Takeshi
AU  - Komeyama T
AD  - Department of Urology, Nagaoka Red Cross Hospital, Niigata, Japan.
FAU - Sato, Kazuhiro
AU  - Sato K
AD  - Department of Respiratory Medicine, Nagaoka Red Cross Hospital, Niigata, Japan.
FAU - Togashi, Kenichi
AU  - Togashi K
AD  - Department of Thoracic Surgery, Nagaoka Red Cross Hospital, Niigata, Japan.
FAU - Usuda, Hiroyuki
AU  - Usuda H
AD  - Department of Pathology, Nagaoka Red Cross Hospital, Niigata, Japan.
FAU - Yamazaki, Yuto
AU  - Yamazaki Y
AD  - Department of Pathology, Tohoku University Graduate School of Medicine, Miyagi, 
      Japan.
FAU - Sasano, Hironobu
AU  - Sasano H
AD  - Department of Pathology, Tohoku University Graduate School of Medicine, Miyagi, 
      Japan.
FAU - Kaneko, Kenzo
AU  - Kaneko K
AD  - Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Niigata, 
      Japan.
FAU - Kamoi, Kyuzi
AU  - Kamoi K
AD  - Department of Internal Medicine, Ojiya General Hospital, Niigata, Japan; Center 
      of Diabetes, Endocrinology and Metabolism, Joetsu General Hospital, Niigata, 
      Japan.
LA  - eng
PT  - Case Reports
DEP - 20161218
PL  - England
TA  - Respir Med Case Rep
JT  - Respiratory medicine case reports
JID - 101604463
PMC - PMC5219631
OTO - NOTNLM
OT  - ACC, adrenocortical carcinoma
OT  - ALK, anaplastic lymphoma kinase
OT  - Adrenocortical carcinoma
OT  - CT, computed tomography
OT  - EGFR, epidermal growth factor receptor
OT  - Epidermal growth factor receptor gene mutation
OT  - Immunohistochemistry
OT  - LAC, lung adenocarcinoma
OT  - Lung adenocarcinoma
OT  - MEN1, multiple endocrine neoplasia type 1
OT  - MRI, magnetic resonance imaging
OT  - Menin
OT  - Multiple endocrine neoplasia type 1
OT  - SF-1, steroidogenic factor
OT  - TTF-1, thyroid transcription factor-1
EDAT- 2017/01/11 06:00
MHDA- 2017/01/11 06:01
PMCR- 2016/12/18
CRDT- 2017/01/11 06:00
PHST- 2016/07/01 00:00 [received]
PHST- 2016/12/14 00:00 [revised]
PHST- 2016/12/16 00:00 [accepted]
PHST- 2017/01/11 06:00 [entrez]
PHST- 2017/01/11 06:00 [pubmed]
PHST- 2017/01/11 06:01 [medline]
PHST- 2016/12/18 00:00 [pmc-release]
AID - S2213-0071(16)30216-7 [pii]
AID - 10.1016/j.rmcr.2016.12.002 [doi]
PST - epublish
SO  - Respir Med Case Rep. 2016 Dec 18;20:77-81. doi: 10.1016/j.rmcr.2016.12.002. 
      eCollection 2017.