PMID- 28071586
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180924
IS  - 1874-4702 (Electronic)
IS  - 1874-4672 (Linking)
VI  - 10
IP  - 4
DP  - 2017
TI  - Milestones in CRH Research.
PG  - 259-263
LID - 10.2174/1874467210666170109165219 [doi]
AB  - The Corticotropin-releasing Hormone (CRH) mammalian family members include CRH, 
      urocortin I, Stresscopin (SCP) and Stresscopin-related peptide (SRP), along with 
      the CRH receptors type 1 (CRHR1) and type 2 (CRHR2), and CRH-binding protein 
      (CRH-BP). These family members differ in their tissue distribution and 
      pharmacology. Several studies have provided evidence supporting an important role 
      of this family in the regulation of the neuroendocrine and behavioral responses 
      to stress. Regulation of the relative contribution of CRH and its homologs and 
      the two CRH receptors in brain CRH pathways may be essential in coordinating 
      physiologic responses to stress. The development of disorders related to 
      heightened stress sensitivity and dysregulation of stress-coping mechanisms 
      appears to involve regulatory mechanisms of the CRH family members. Therapeutic 
      agents that target CRH family members may offer a new approach to the treatment 
      of these disorders. The purpose of this review is to summarize the most 
      significant discoveries related to CRH over time.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Chrousos, George P
AU  - Chrousos GP
AD  - First Department of Pediatrics, National and Kapodistrian University of Athens 
      Medical School, Aghia Sophia Children's Hospital, Athens. Greece.
FAU - Zoumakis, Emmanouil
AU  - Zoumakis E
AD  - First Department of Pediatrics, National and Kapodistrian University of Athens 
      Medical School, Aghia Sophia Children's Hospital, Athens. Greece.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Mol Pharmacol
JT  - Current molecular pharmacology
JID - 101467997
RN  - 0 (Carrier Proteins)
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 0 (Urocortins)
RN  - 134773-81-2 (corticotropin releasing factor-binding protein)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Carrier Proteins/metabolism
MH  - Corticotropin-Releasing Hormone/*metabolism
MH  - Humans
MH  - Receptors, Corticotropin-Releasing Hormone/metabolism
MH  - Signal Transduction
MH  - *Stress, Physiological
MH  - Urocortins/metabolism
OTO - NOTNLM
OT  - CRH
OT  - antalarmin
OT  - general adaptation syndrome
OT  - stress
OT  - stresscopin
OT  - urocortin
EDAT- 2017/01/11 06:00
MHDA- 2018/06/05 06:00
CRDT- 2017/01/11 06:00
PHST- 2016/01/13 00:00 [received]
PHST- 2016/04/19 00:00 [revised]
PHST- 2016/08/03 00:00 [accepted]
PHST- 2017/01/11 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2017/01/11 06:00 [entrez]
AID - CMP-EPUB-80926 [pii]
AID - 10.2174/1874467210666170109165219 [doi]
PST - ppublish
SO  - Curr Mol Pharmacol. 2017;10(4):259-263. doi: 10.2174/1874467210666170109165219.