PMID- 28072974
OWN - NLM
STAT- MEDLINE
DCOM- 20170719
LR  - 20231213
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 46
IP  - 1
DP  - 2017 Jan 8
TI  - [Clinicopathologic features of mammary analogue secretory carcinoma of salivary 
      glands].
PG  - 34-37
LID - 10.3760/cma.j.issn.0529-5807.2017.01.008 [doi]
AB  - Objective: To investigate the clinicopathological features of mammary analogue 
      secretory carcinoma (MASC) of salivary glands, and its diagnosis, differential 
      diagnosis, immunohistochemistry and molecular pathology. Methods: Seventeen cases 
      of MASC were enrolled, with 9 cases of salivary acinar cell carcinoma and 18 
      cases of adenoid cystic carcinoma as control groups from Nanjing General Hospital 
      from 1997 to 2014 were included in this retrospective study, combined with 
      immunohistochemistry and molecular detection of ETV6-NTRK3 gene fusion. All cases 
      were histologically reviewed with immunohistochemical staining (EnVision) for 
      S-100 protein, SOX10, GATA3, CD117 expression in each group. Fluorescence in situ 
      hybridization (FISH) was used to detect the ETV6-NTRK3 gene fusion. Results: The 
      age of MASC patients ranged from 27 to 74 years with mean age of 47 and ratio of 
      male and female was 4ratio3. All cases showed infiltrative growth and diverse 
      cytology and histology, including lobular (8 cases), cystic papillary (3 cases), 
      cribriform mixed with papillary and glandular structures (6 cases) at various 
      proportions. Some tumors of MASC also exhibited solid growth areas with 
      occasional microcystic honeycombed pattern composed of small cysts merged into 
      larger cysts resembling thyroid follicles. S-100 protein and SOX10 were strongly 
      positive in all MASC cases (17/17). In addition, there was insignificant 
      positivity for GATA3 (3/17) and CD117 (4/17). ETV6 gene fusion detection was 
      informative in 12 MASC cases by FISH with 10 positive cases and 2 negative cases. 
      Conclusions: Combined immunohistochemical positivity of S-100 protein, CD117 and 
      SOX10 are useful in the diagnosis and differential diagnosis of MASC. FISH 
      detection of ETV6-NTRK3 fusion offers an additional molecular diagnostic marker 
      for the diagnosis.
FAU - Zhang, X P
AU  - Zhang XP
AD  - Department of Pathology, Medicine School of Nanjing University/Nanjing Jinling 
      Hospital, Nanjing 210002, China.
FAU - Ni, H
AU  - Ni H
FAU - Wang, X
AU  - Wang X
FAU - Chen, H
AU  - Chen H
FAU - Shi, S S
AU  - Shi SS
FAU - Yu, B
AU  - Yu B
FAU - Zhou, X J
AU  - Zhou XJ
FAU - Rao, Q
AU  - Rao Q
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (Repressor Proteins)
RN  - 0 (S100 Proteins)
RN  - 0 (SOX10 protein, human)
RN  - 0 (SOXE Transcription Factors)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoma, Acinar Cell/diagnosis/genetics/*pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - GATA3 Transcription Factor/analysis
MH  - Gene Fusion
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mammary Analogue Secretory Carcinoma/diagnosis/genetics/*pathology
MH  - Middle Aged
MH  - Oncogene Proteins, Fusion
MH  - Proto-Oncogene Proteins c-ets/genetics
MH  - Proto-Oncogene Proteins c-kit/analysis
MH  - Receptor, trkC/genetics
MH  - Repressor Proteins/genetics
MH  - Retrospective Studies
MH  - S100 Proteins/analysis
MH  - SOXE Transcription Factors/analysis
MH  - Salivary Gland Neoplasms/diagnosis/genetics/*pathology
MH  - Salivary Glands
MH  - ETS Translocation Variant 6 Protein
EDAT- 2017/01/11 06:00
MHDA- 2017/07/20 06:00
CRDT- 2017/01/11 06:00
PHST- 2017/01/11 06:00 [entrez]
PHST- 2017/01/11 06:00 [pubmed]
PHST- 2017/07/20 06:00 [medline]
AID - 10.3760/cma.j.issn.0529-5807.2017.01.008 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2017 Jan 8;46(1):34-37. doi: 
      10.3760/cma.j.issn.0529-5807.2017.01.008.