PMID- 28073060
OWN - NLM
STAT- MEDLINE
DCOM- 20170323
LR  - 20200106
IS  - 2299-5684 (Electronic)
IS  - 1734-1140 (Linking)
VI  - 69
IP  - 2
DP  - 2017 Apr
TI  - Acute behavioral effects of co-administration of mephedrone and MDMA in mice.
PG  - 199-205
LID - S1734-1140(16)30268-7 [pii]
LID - 10.1016/j.pharep.2016.10.006 [doi]
AB  - BACKGROUND: Abuse of more than one psychoactive drug is becoming a global 
      problem. Our experiments were designed to examine the effects of a concomitant 
      administration of 3,4-methylenedioxy-methamphetamine (MDMA) and mephedrone on 
      depression- and anxiety-like behaviors and cognitive processes in Swiss mice. 
      METHODS: In order to investigate the drug interactions the forced swimming test 
      (FST) - an animal model of depression, the passive avoidance (PA) test - a memory 
      and learning paradigm, as well as the elevated plus maze (EPM) test - test for 
      anxiety level were used. RESULTS: The results revealed that a concomitant 
      administration of non-effective doses of mephedrone (1mg/kg) and MDMA (1mg/kg) 
      exerted marked antidepressive effects in the FST. Also a co-administration of 
      mephedrone (2.5mg/kg) and MDMA (1mg/kg) displayed a pro-cognitive action in the 
      PA paradigm. Furthermore, even though mephedrone and MDMA can, in general, exert 
      some anxiogenic effects in mice, the concomitant administration of nonactive 
      doses of both drugs (0.05 and 0.1mg/kg, respectively) in the EPM test, did not 
      show any synergistic effect in our study. CONCLUSIONS: The effects of mephedrone 
      and MDMA combination on mammalian organisms were attempted to be evaluated in our 
      study and the results are described in the present report. These results may help 
      explain the reasons for and consequences of a concomitant administration of 
      psychoactive substances with regards to the central nervous system, while being 
      possibly useful in the treatment of polydrug intoxication.
CI  - Copyright (c) 2016. Published by Elsevier Urban & Partner Sp. z o.o.
FAU - Budzynska, Barbara
AU  - Budzynska B
AD  - Medical University of Lublin, Department of Pharmacology and Pharmacodynamics, 
      Lublin, Poland. Electronic address: basia.budzynska@umlub.pl.
FAU - Michalak, Agnieszka
AU  - Michalak A
AD  - Medical University of Lublin, Department of Pharmacology and Pharmacodynamics, 
      Lublin, Poland.
FAU - Frankowska, Malgorzata
AU  - Frankowska M
AD  - Institute of Pharmacology, Polish Academy of Sciences, Department of 
      Pharmacology, Krakow, Poland.
FAU - Kaszubska, Katarzyna
AU  - Kaszubska K
AD  - Medical University of Lublin, Department of Pharmacology and Pharmacodynamics, 
      Lublin, Poland.
FAU - Biala, Grazyna
AU  - Biala G
AD  - Medical University of Lublin, Department of Pharmacology and Pharmacodynamics, 
      Lublin, Poland.
LA  - eng
PT  - Journal Article
DEP - 20161011
PL  - Switzerland
TA  - Pharmacol Rep
JT  - Pharmacological reports : PR
JID - 101234999
RN  - 0 (Antidepressive Agents)
RN  - 44RAL3456C (Methamphetamine)
RN  - 8BA8T27317 (mephedrone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/administration & dosage
MH  - Anxiety/*drug therapy
MH  - Cognition/drug effects
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Drug Interactions
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory/drug effects
MH  - Methamphetamine/administration & dosage/*analogs & derivatives
MH  - Mice
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Swimming
OTO - NOTNLM
OT  - Anxiety
OT  - Depression
OT  - MDMA
OT  - Memory
OT  - Mephedrone
OT  - Mice
EDAT- 2017/01/11 06:00
MHDA- 2017/03/24 06:00
CRDT- 2017/01/11 06:00
PHST- 2016/07/22 00:00 [received]
PHST- 2016/10/07 00:00 [revised]
PHST- 2016/10/07 00:00 [accepted]
PHST- 2017/01/11 06:00 [pubmed]
PHST- 2017/03/24 06:00 [medline]
PHST- 2017/01/11 06:00 [entrez]
AID - S1734-1140(16)30268-7 [pii]
AID - 10.1016/j.pharep.2016.10.006 [doi]
PST - ppublish
SO  - Pharmacol Rep. 2017 Apr;69(2):199-205. doi: 10.1016/j.pharep.2016.10.006. Epub 
      2016 Oct 11.