PMID- 28073242
OWN - NLM
STAT- MEDLINE
DCOM- 20190313
LR  - 20190313
IS  - 2005-6648 (Electronic)
IS  - 1226-3303 (Print)
IS  - 1226-3303 (Linking)
VI  - 33
IP  - 5
DP  - 2018 Sep
TI  - Clinical phenotypes of Korean patients with Behcet disease according to gender, 
      age at onset, and HLA-B51.
PG  - 1025-1031
LID - 10.3904/kjim.2016.202 [doi]
AB  - BACKGROUND/AIMS: The clinical manifestations of Behcet disease (BD) have been 
      reported to differ according to country, region, and race. Gender, onset age, and 
      human leukocyte antigen (HLA)-B51 have also been known as the factors that 
      influence the clinical features of BD. The aim of this study is to investigate 
      the clinical phenotypes of Korean patients who visited the rheumatology clinic 
      with BD with respect to gender, onset age, and HLA-B51. METHODS: Total 193 Korean 
      patients (129 females and 64 males) fulfilling the international criteria for BD 
      were retrospectively assessed. RESULTS: The mean age at disease onset and disease 
      duration of the BD patients were 32.2 +/- 11.1 and 14.2 +/- 9.3 years, 
      retrospectively. Females suffered more frequently from genital ulcers (90.7% vs. 
      75.0%, p < 0.01), peripheral arthritis (67.4% vs. 43.8%, p < 0.01), and inf 
      lammatory low back pain (38.8% vs. 23.4%, p = 0.03) than males, while skin 
      involvement was more frequent in males than in females (90.6% vs. 75.2%, p = 
      0.01). The patients with late onset of BD (> 40 years) suffered from neurologic 
      involvement (15.9% vs. 4.2%, p = 0.007) more frequently than those with early 
      onset of BD. The patients with HLA-B51 showed earlier onset of disease than 
      without HLA-B51 (28.3 +/- 11.4 years vs. 33.8+/-11.6 years, p = 0.02) and the 
      neurologic and gastrointestinal involvements were more frequent in the patients 
      without HLA-B51 than with HLA-B51 (17.2% vs. 2.5%, p = 0.02 and 20.7% vs. 2.5%, p 
      = 0.01, respectively). CONCLUSION: The clinical phenotypes in Korean patients 
      with BD may be influenced by gender, onset age and HLA-B51.
FAU - Ryu, Hee Jung
AU  - Ryu HJ
AD  - Department of Rheumatology, Gachon University Gil Medical Center, Incheon, Korea.
FAU - Seo, Mi Ryoung
AU  - Seo MR
AD  - Department of Rheumatology, Gachon University Gil Medical Center, Incheon, Korea.
FAU - Choi, Hyo Jin
AU  - Choi HJ
AD  - Department of Rheumatology, Gachon University Gil Medical Center, Incheon, Korea.
FAU - Baek, Han Joo
AU  - Baek HJ
AD  - Department of Rheumatology, Gachon University Gil Medical Center, Incheon, Korea.
LA  - eng
GR  - 2013-03/Gachon University Gil Medical Center/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170112
PL  - Korea (South)
TA  - Korean J Intern Med
JT  - The Korean journal of internal medicine
JID - 8712418
RN  - 0 (HLA-B51 Antigen)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - *Behcet Syndrome/complications/diagnosis/immunology
MH  - Female
MH  - HLA-B51 Antigen
MH  - Humans
MH  - Male
MH  - *Phenotype
MH  - Retrospective Studies
MH  - Sex Factors
MH  - Young Adult
PMC - PMC6129630
OTO - NOTNLM
OT  - Age of onset
OT  - Behcet syndrome
OT  - Gender identity
OT  - HLA-B51 antigen
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2017/01/12 06:00
MHDA- 2019/03/14 06:00
PMCR- 2018/09/01
CRDT- 2017/01/12 06:00
PHST- 2016/05/26 00:00 [received]
PHST- 2016/10/23 00:00 [accepted]
PHST- 2017/01/12 06:00 [pubmed]
PHST- 2019/03/14 06:00 [medline]
PHST- 2017/01/12 06:00 [entrez]
PHST- 2018/09/01 00:00 [pmc-release]
AID - kjim.2016.202 [pii]
AID - kjim-2016-202 [pii]
AID - 10.3904/kjim.2016.202 [doi]
PST - ppublish
SO  - Korean J Intern Med. 2018 Sep;33(5):1025-1031. doi: 10.3904/kjim.2016.202. Epub 
      2017 Jan 12.