PMID- 28076310
OWN - NLM
STAT- MEDLINE
DCOM- 20170821
LR  - 20220330
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 55
IP  - 9
DP  - 2017 Aug 28
TI  - The serum concentrations of leptin and MCP-1 independently predict low back pain 
      duration.
PG  - 1368-1374
LID - 10.1515/cclm-2016-0942 [doi]
AB  - BACKGROUND: Low back pain (LBP) is a very frequent condition, affecting most 
      people at some point throughout their life. This cross-sectional study was aimed 
      to investigate a selected panel of cytokines and inflammatory biomarkers in 
      patients with or without LBP. METHODS: The study population consisted of 104 
      patients diagnosed with LBP (52 non-persistent and 52 persistent) and 52 healthy 
      subjects with no LBP. Blood samples were collected for assessment of adiponectin, 
      leptin, monocyte chemoattractant protein-1 (MCP-1) and C reactive protein (CRP). 
      The duration of LBP was categorized as "no pain", "non-persistent LBP" and 
      "persistent LBP". RESULTS: Higher values of CRP and lower concentrations of both 
      leptin and MCP-1 were found in LBP patients compared to controls, whereas 
      adiponectin did not differ among groups. MCP-1 was also lower in patients with 
      non-persistent than in those with persistent LBP. Age, leptin (relative risk, 
      11.8; 95% CI, 3.9-35.8) and MCP-1 (relative risk, 2.7; 95% CI, 1.7-4.4) were 
      independently associated with presence and duration of LBP. The combination of 
      age, leptin and MCP-1 predicted 61% of the risk of LBP duration. The area under 
      the curve of MCP-1 for distinguishing persistent from non-persistent LBP was 0.65 
      (95% CI, 0.54-0.76). CONCLUSIONS: Then results of our study suggest that leptin 
      and MCP-1 may be promising biomarkers for diagnosis of acute LBP and its risk to 
      become chronic.
FAU - Lippi, Giuseppe
AU  - Lippi G
AUID- ORCID: 0000-0001-9523-9054
AD  - .
FAU - Dagostino, Concetta
AU  - Dagostino C
AD  - .
FAU - Buonocore, Ruggero
AU  - Buonocore R
AD  - .
FAU - Aloe, Rosalia
AU  - Aloe R
AD  - .
FAU - Bonaguri, Chiara
AU  - Bonaguri C
AD  - .
FAU - Fanelli, Guido
AU  - Fanelli G
AD  - .
FAU - Allegri, Massimo
AU  - Allegri M
AD  - .
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Leptin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - C-Reactive Protein/analysis
MH  - Chemokine CCL2/*blood
MH  - Chronic Pain/blood/diagnosis
MH  - Female
MH  - Humans
MH  - Leptin/*blood
MH  - Low Back Pain/*blood/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Time Factors
OTO - NOTNLM
OT  - MCP-1
OT  - biomarkers
OT  - leptin
OT  - low back pain
OT  - pain
EDAT- 2017/01/12 06:00
MHDA- 2017/08/22 06:00
CRDT- 2017/01/12 06:00
PHST- 2016/11/10 00:00 [received]
PHST- 2016/12/03 00:00 [accepted]
PHST- 2017/01/12 06:00 [pubmed]
PHST- 2017/08/22 06:00 [medline]
PHST- 2017/01/12 06:00 [entrez]
AID - /j/cclm.ahead-of-print/cclm-2016-0942/cclm-2016-0942.xml [pii]
AID - 10.1515/cclm-2016-0942 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2017 Aug 28;55(9):1368-1374. doi: 10.1515/cclm-2016-0942.