PMID- 28077133
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 19
IP  - 1
DP  - 2017 Jan 6
TI  - T1 and T2 mapping for evaluation of myocardial involvement in patients with 
      ANCA-associated vasculitides.
PG  - 6
LID - 10.1186/s12968-016-0315-5 [doi]
LID - 6
AB  - BACKGROUND: Myocardial involvement in AAV patients might be silent, presenting 
      with no or nonspecific symptoms, normal ECG, and preserved left-ventricular 
      ejection fraction (LV-EF). Since up to 50% of deaths in these patients may be due 
      to myocardial involvement, a reliable diagnostic tool is warranted. In contrast 
      to LGE-CMR, which has its strengths in detecting focal inflammatory or fibrotic 
      processes, recent mapping techniques are able to detect even subtle, diffuse 
      inflammatory or fibrotic processes. Our study sought to investigate ANCA 
      (antineutrophil cytoplasmic antibody) associated vasculitides (AAV) patients for 
      myocardial involvement by a cardiovascular magnetic resonance (CMR) protocol, 
      including late gadolinium enhancement (LGE) and mapping sequences. METHODS: 
      Thirty seven AAV patients were prospectively enrolled and underwent CMR imaging. 
      Twenty healthy volunteers served as controls. RESULTS: Mean LV-EF was 64%; LGE 
      prevalence of the AAV patients was 43%. AAV patients had higher median native T1 
      (988 vs. 952 ms, p < 0.001), lower post-contrast T1 (488 vs. 524 ms, p = 0.03), 
      expanded extracellular volume (ECV) (27.5 vs. 24.5%, p < 0.001), and higher T2 
      (53 vs. 49 ms, p < 0.001) compared to controls, with most parameters independent 
      of the LGE status. Native T1 and T2 in AAV patients showed the highest prevalence 
      of abnormally increased values beyond the 95% percentile of controls. CONCLUSION: 
      AAV patients demonstrated increased T1, ECV, and T2 values, with native T1 and T2 
      showing the highest prevalence of values beyond the 95% percentile of normal. 
      Since these findings seem to be independent of LGE, mapping techniques may 
      provide complementary information to LGE-CMR in the assessment of myocardial 
      involvement in patients with AAV.
FAU - Greulich, Simon
AU  - Greulich S
AD  - Division of Cardiology, Robert-Bosch-Medical Center, Auerbachstrasse 110, 70376, 
      Stuttgart, Germany. simon.greulich@rbk.de.
FAU - Mayr, Agnes
AU  - Mayr A
AD  - Division of Radiology, University Hospital Innsbruck, Innsbruck, Austria.
FAU - Kitterer, Daniel
AU  - Kitterer D
AD  - Division of Nephrology, Department of Internal Medicine, Robert-Bosch-Medical 
      Center, Stuttgart, Germany.
FAU - Latus, Joerg
AU  - Latus J
AD  - Division of Nephrology, Department of Internal Medicine, Robert-Bosch-Medical 
      Center, Stuttgart, Germany.
FAU - Henes, Joerg
AU  - Henes J
AD  - Center for Interdisciplinary Clinical Immunology, Rheumatology and 
      Auto-inflammatory Diseases, University Hospital Tuebingen, Tuebingen, Germany.
FAU - Steubing, Hannah
AU  - Steubing H
AD  - Division of Cardiology, Robert-Bosch-Medical Center, Auerbachstrasse 110, 70376, 
      Stuttgart, Germany.
FAU - Kaesemann, Philipp
AU  - Kaesemann P
AD  - Division of Cardiology, Robert-Bosch-Medical Center, Auerbachstrasse 110, 70376, 
      Stuttgart, Germany.
FAU - Patrascu, Alexandru
AU  - Patrascu A
AD  - Division of Cardiology, Robert-Bosch-Medical Center, Auerbachstrasse 110, 70376, 
      Stuttgart, Germany.
FAU - Greiser, Andreas
AU  - Greiser A
AD  - Siemens Healthcare GmbH, Erlangen, Germany.
FAU - Groeninger, Stefan
AU  - Groeninger S
AD  - Siemens Healthcare GmbH, Erlangen, Germany.
FAU - Braun, Niko
AU  - Braun N
AD  - Division of Nephrology, Department of Internal Medicine, Robert-Bosch-Medical 
      Center, Stuttgart, Germany.
FAU - Alscher, M Dominik
AU  - Alscher MD
AD  - Division of Nephrology, Department of Internal Medicine, Robert-Bosch-Medical 
      Center, Stuttgart, Germany.
FAU - Sechtem, Udo
AU  - Sechtem U
AD  - Division of Cardiology, Robert-Bosch-Medical Center, Auerbachstrasse 110, 70376, 
      Stuttgart, Germany.
FAU - Mahrholdt, Heiko
AU  - Mahrholdt H
AD  - Division of Cardiology, Robert-Bosch-Medical Center, Auerbachstrasse 110, 70376, 
      Stuttgart, Germany.
LA  - eng
PT  - Journal Article
DEP - 20170106
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathies/*diagnostic imaging/etiology/pathology/physiopathology
MH  - Case-Control Studies
MH  - Churg-Strauss Syndrome/*complications/diagnosis
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA/administration & dosage
MH  - Granulomatosis with Polyangiitis/*complications/diagnosis
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocarditis/*diagnostic imaging/etiology/pathology/physiopathology
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Stroke Volume
MH  - Ventricular Function, Left
PMC - PMC5225624
OTO - NOTNLM
OT  - ANCA-associated vasculitides
OT  - CMR
OT  - Cardiac involvement
OT  - LGE
OT  - T1 mapping
OT  - T2 mapping
EDAT- 2017/01/13 06:00
MHDA- 2017/12/13 06:00
PMCR- 2017/01/06
CRDT- 2017/01/13 06:00
PHST- 2016/10/16 00:00 [received]
PHST- 2016/12/09 00:00 [accepted]
PHST- 2017/01/13 06:00 [entrez]
PHST- 2017/01/13 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2017/01/06 00:00 [pmc-release]
AID - S1097-6647(23)01040-2 [pii]
AID - 315 [pii]
AID - 10.1186/s12968-016-0315-5 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2017 Jan 6;19(1):6. doi: 10.1186/s12968-016-0315-5.