PMID- 28077213
OWN - NLM
STAT- MEDLINE
DCOM- 20170814
LR  - 20181108
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 303
DP  - 2017 Feb 15
TI  - Inhibition of dopamine receptor D3 signaling in dendritic cells increases antigen 
      cross-presentation to CD8(+) T-cells favoring anti-tumor immunity.
PG  - 99-107
LID - S0165-5728(16)30366-6 [pii]
LID - 10.1016/j.jneuroim.2016.12.014 [doi]
AB  - Dendritic cells (DCs) display the unique ability for cross-presenting antigens to 
      CD8(+) T-cells, promoting their differentiation into cytotoxic T-lymphocytes 
      (CTLs), which play a pivotal role in anti-tumor immunity. Emerging evidence 
      points to dopamine receptor D3 (D3R) as a key regulator of immunity. Accordingly, 
      we studied how D3R regulates DCs function in anti-tumor immunity. The results 
      show that D3R-deficiency in DCs enhanced expansion of CTLs in vivo and induced 
      stronger anti-tumor immunity. Co-culture experiments indicated that 
      D3R-inhibition in DCs potentiated antigen cross-presentation and CTLs activation. 
      Our findings suggest that D3R in DCs constitutes a new therapeutic target to 
      strengthen anti-tumor immunity.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Figueroa, Claudio
AU  - Figueroa C
AD  - Laboratorio de Neuroinmunologia, Fundacion Ciencia & Vida, Nunoa, 7780272 
      Santiago, Chile; Departamento de Ciencias Biologicas y Quimicas, Facultad de 
      Ciencia, Universidad San Sebastian, Providencia, 7510157 Santiago, Chile.
FAU - Galvez-Cancino, Felipe
AU  - Galvez-Cancino F
AD  - Laboratorio de Inmunoterapia Genica, Fundacion Ciencia & Vida, Nunoa, 7780272 
      Santiago, Chile; Departamento de Ciencias Biologicas, Facultad de Ciencias 
      Biologicas, Universidad Andres Bello, 8370146 Santiago, Chile.
FAU - Oyarce, Cesar
AU  - Oyarce C
AD  - Laboratorio de Inmunoterapia Genica, Fundacion Ciencia & Vida, Nunoa, 7780272 
      Santiago, Chile.
FAU - Contreras, Francisco
AU  - Contreras F
AD  - Laboratorio de Neuroinmunologia, Fundacion Ciencia & Vida, Nunoa, 7780272 
      Santiago, Chile.
FAU - Prado, Carolina
AU  - Prado C
AD  - Laboratorio de Neuroinmunologia, Fundacion Ciencia & Vida, Nunoa, 7780272 
      Santiago, Chile.
FAU - Valeria, Catalina
AU  - Valeria C
AD  - Laboratorio de Neuroinmunologia, Fundacion Ciencia & Vida, Nunoa, 7780272 
      Santiago, Chile.
FAU - Cruz, Sebastian
AU  - Cruz S
AD  - Laboratorio de Inmunoterapia Genica, Fundacion Ciencia & Vida, Nunoa, 7780272 
      Santiago, Chile.
FAU - Lladser, Alvaro
AU  - Lladser A
AD  - Laboratorio de Inmunoterapia Genica, Fundacion Ciencia & Vida, Nunoa, 7780272 
      Santiago, Chile.
FAU - Pacheco, Rodrigo
AU  - Pacheco R
AD  - Laboratorio de Neuroinmunologia, Fundacion Ciencia & Vida, Nunoa, 7780272 
      Santiago, Chile; Departamento de Ciencias Biologicas, Facultad de Ciencias 
      Biologicas, Universidad Andres Bello, 8370146 Santiago, Chile. Electronic 
      address: rpacheco@cienciavida.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170102
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Receptors, Dopamine D3)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Antigens, Neoplasm/*immunology/metabolism
MH  - CD8-Positive T-Lymphocytes/*immunology/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Male
MH  - Melanoma, Experimental/immunology/metabolism
MH  - Mice
MH  - Mice, 129 Strain
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Receptors, Dopamine D3/*deficiency/*immunology
MH  - Signal Transduction/immunology
MH  - Tumor Burden/*immunology
OTO - NOTNLM
OT  - Antigen cross-presentation
OT  - Cytotoxic T lymphocytes
OT  - Dendritic cells
OT  - Dopamine receptors
OT  - Knockout mice
OT  - Tumor immunology
EDAT- 2017/01/13 06:00
MHDA- 2017/08/15 06:00
CRDT- 2017/01/13 06:00
PHST- 2016/10/26 00:00 [received]
PHST- 2016/12/06 00:00 [revised]
PHST- 2016/12/28 00:00 [accepted]
PHST- 2017/01/13 06:00 [pubmed]
PHST- 2017/08/15 06:00 [medline]
PHST- 2017/01/13 06:00 [entrez]
AID - S0165-5728(16)30366-6 [pii]
AID - 10.1016/j.jneuroim.2016.12.014 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2017 Feb 15;303:99-107. doi: 10.1016/j.jneuroim.2016.12.014. Epub 
      2017 Jan 2.