PMID- 28077780
OWN - NLM
STAT- MEDLINE
DCOM- 20180426
LR  - 20240318
IS  - 1096-0929 (Electronic)
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 155
IP  - 2
DP  - 2017 Feb
TI  - Editor's Highlight: Exposure to CrVI during Early Pregnancy Increases Oxidative 
      Stress and Disrupts the Expression of Antioxidant Proteins in Placental 
      Compartments.
PG  - 497-511
LID - 10.1093/toxsci/kfw231 [doi]
AB  - Epidemiologic studies document relationships between chromium VI (CrVI) exposure 
      and increased risk of spontaneous abortion, stillbirth, preterm birth, and 
      neonatal death in pregnant women. Environmental contamination with CrVI is a 
      growing problem both in the United States and developing countries. CrVI is 
      widely used in numerous industries. This study was designed to understand the 
      mechanism of CrVI toxicity on placental oxidative stress and antioxidant (AOX) 
      machinery. Pregnant mother rats were treated with or without CrVI (50 ppm 
      K(2)Cr(2)O(7)) through drinking water from gestational day (GD) 9.5-14.5, and 
      placentas were analyzed on GD 18.5. Results indicated that CrVI reduced the 
      trophoblast cell population. CrVI increased reactive oxygen species (ROS) and 
      decreased the expression of AOX proteins. CrVI disrupts the trophoblast 
      proliferation of the placenta. This study provides insight into the critical role 
      of AOXs in placental function.
CI  - (c) The Author 2016. Published by Oxford University Press on behalf of the Society 
      of Toxicology. All rights reserved. For Permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Banu, Sakhila K
AU  - Banu SK
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine 
      and Biomedical Sciences, Mail stop TAMU 4458, Texas A&M University, College 
      Station, Texas 77843 skbanu@cvm.tamu.edu.
FAU - Stanley, Jone A
AU  - Stanley JA
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine 
      and Biomedical Sciences, Mail stop TAMU 4458, Texas A&M University, College 
      Station, Texas 77843.
FAU - Sivakumar, Kirthiram K
AU  - Sivakumar KK
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine 
      and Biomedical Sciences, Mail stop TAMU 4458, Texas A&M University, College 
      Station, Texas 77843.
FAU - Taylor, Robert J
AU  - Taylor RJ
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine 
      and Biomedical Sciences, Mail stop TAMU 4458, Texas A&M University, College 
      Station, Texas 77843.
FAU - Arosh, Joe A
AU  - Arosh JA
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine 
      and Biomedical Sciences, Mail stop TAMU 4458, Texas A&M University, College 
      Station, Texas 77843.
FAU - Burghardt, Robert C
AU  - Burghardt RC
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine 
      and Biomedical Sciences, Mail stop TAMU 4458, Texas A&M University, College 
      Station, Texas 77843.
LA  - eng
GR  - P30 ES023512/ES/NIEHS NIH HHS/United States
GR  - R01 ES025234/ES/NIEHS NIH HHS/United States
GR  - S10 RR022532/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20161115
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Environmental Pollutants)
RN  - 0R0008Q3JB (Chromium)
RN  - 18540-29-9 (chromium hexavalent ion)
SB  - IM
MH  - Animals
MH  - Cell Proliferation/drug effects
MH  - Chromium/*toxicity
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - *Maternal Exposure
MH  - *Oxidative Stress
MH  - Placenta/cytology/*drug effects/enzymology
MH  - Pregnancy
MH  - Rats
MH  - Trophoblasts/drug effects
PMC - PMC5291216
OTO - NOTNLM
OT  - Gpx1
OT  - Prdx3.
OT  - Sod
OT  - oxidative stress
OT  - rat placenta and chromium
OT  - trophoblast
EDAT- 2017/01/13 06:00
MHDA- 2018/04/27 06:00
PMCR- 2018/02/01
CRDT- 2017/01/13 06:00
PHST- 2017/01/13 06:00 [pubmed]
PHST- 2018/04/27 06:00 [medline]
PHST- 2017/01/13 06:00 [entrez]
PHST- 2018/02/01 00:00 [pmc-release]
AID - kfw231 [pii]
AID - 10.1093/toxsci/kfw231 [doi]
PST - ppublish
SO  - Toxicol Sci. 2017 Feb;155(2):497-511. doi: 10.1093/toxsci/kfw231. Epub 2016 Nov 
      15.