PMID- 28078033
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 8
IP  - 12
DP  - 2016
TI  - Bone marrow-derived mesenchymal stem cells reduce immune reaction in a mouse 
      model of allergic rhinitis.
PG  - 5628-5636
AB  - OBJECT: To determine the potential of bone marrow-derived mesenchymal stem cells 
      (BMSCs) for immunomodulatory mechanism in mice model of allergic rhinitis (AR). 
      METHODS: BMSCs were isolated and the surface markers and stemness were analyzed. 
      The effect of BMSCs was evaluated in BALB/c mice that were randomly divided into 
      three groups (control group, ovalbumin (OVA) group, OVA+BMSCs group). BMSCs were 
      administered intravenously to OVA sensitized mice on days 1, 7, 14 and 21, and 
      subsequent OVA challenge was conducted daily from days 22 to 35. Several 
      parameters of allergic inflammation were assessed. RESULTS: Mesenchymal stem 
      cells can be successfully isolated from bone marrow of mice. Intravenous 
      injection of BMSCs significantly reduced allergic symptoms, eosinophil 
      infiltration, OVA-specific immunoglobulin E (IgE), T-helper 2 (Th2) cytokine 
      profile (interleukin (IL)-4, IL-5 and IL-13) and regulatory cytokines (IL-10). In 
      addition, level of Th1 (IFN-gamma) was significantly increased. CONCLUSION: 
      Administration of BMSCs effectively reduced allergic symptoms and inflammatory 
      parameters in the mice model of AR. BMSCs treatment is potentially an alternative 
      therapeutic modality in AR.
FAU - Zhao, Ning
AU  - Zhao N
AD  - Department of E. N. T., The First Hospital Affiliated of China Medical University 
      155 Nanjing Bei Street, Shenyang 110001, China.
FAU - Liu, Yanjuan
AU  - Liu Y
AD  - Department of E. N. T., The First Hospital Affiliated of China Medical University 
      155 Nanjing Bei Street, Shenyang 110001, China.
FAU - Liang, Hongfeng
AU  - Liang H
AD  - Department of E. N. T., The First Hospital Affiliated of Dalian Medical 
      University 222 Zhongshan Road, Dalian 116013, China.
FAU - Jiang, Xuejun
AU  - Jiang X
AD  - Department of E. N. T., The First Hospital Affiliated of China Medical University 
      155 Nanjing Bei Street, Shenyang 110001, China.
LA  - eng
PT  - Journal Article
DEP - 20161215
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC5209513
OTO - NOTNLM
OT  - Cell therapy
OT  - allergic rhinitis
OT  - cytokines
OT  - immunosuppression
OT  - mesenchymal stem cell
EDAT- 2017/01/13 06:00
MHDA- 2017/01/13 06:01
PMCR- 2016/12/15
CRDT- 2017/01/13 06:00
PHST- 2016/06/16 00:00 [received]
PHST- 2016/11/06 00:00 [accepted]
PHST- 2017/01/13 06:00 [entrez]
PHST- 2017/01/13 06:00 [pubmed]
PHST- 2017/01/13 06:01 [medline]
PHST- 2016/12/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2016 Dec 15;8(12):5628-5636. eCollection 2016.