PMID- 28079427
OWN - NLM
STAT- MEDLINE
DCOM- 20180305
LR  - 20180509
IS  - 2047-4881 (Electronic)
IS  - 2047-4873 (Linking)
VI  - 24
IP  - 8
DP  - 2017 May
TI  - Effect of functional electrical stimulation on cardiovascular outcomes in 
      patients with chronic heart failure.
PG  - 833-839
LID - 10.1177/2047487316687428 [doi]
AB  - Background/design Functional electrical stimulation of lower limb muscles is an 
      alternative method of training in patients with chronic heart failure (CHF). 
      Although it improves exercise capacity in CHF, we performed a randomised, 
      placebo-controlled study to investigate its effects on long-term clinical 
      outcomes. Methods We randomly assigned 120 patients, aged 71 +/- 8 years, with 
      stable CHF (New York Heart Association (NYHA) class II/III (63%/37%), mean left 
      ventricular ejection fraction 28 +/- 5%), to either a 6-week functional electrical 
      stimulation training programme or placebo. Patients were followed for up to 19 
      months for death and/or hospitalisation due to CHF decompensation. Results At 
      baseline, there were no significant differences in demographic parameters, CHF 
      severity and medications between groups. During a median follow-up of 383 days, 
      14 patients died (11 cardiac, three non-cardiac deaths), while 40 patients were 
      hospitalised for CHF decompensation. Mortality did not differ between groups (log 
      rank test P = 0.680), while the heart failure-related hospitalisation rate was 
      significantly lower in the functional electrical stimulation group (hazard ratio 
      (HR) 0.40, 95% confidence interval (CI) 0.21-0.78, P = 0.007). The latter 
      difference remained significant after adjustment for prognostic factors: age, 
      gender, baseline NYHA class and left ventricular ejection fraction (HR 0.22, 95% 
      CI 0.10-0.46, P < 0.001). Compared to placebo, functional electrical stimulation 
      training was associated with a lower occurrence of the composite endpoint (death 
      or heart failure-related hospitalisation) after adjustment for the 
      above-mentioned prognostic factors (HR 0.21, 95% CI 0.103-0.435, P < 0.001). 
      However, that effect was mostly driven by the favourable change in 
      hospitalisation rates. Conclusions In CHF patients, 6 weeks functional electrical 
      stimulation training reduced the risk of heart failure-related hospitalisations, 
      without affecting the mortality rate. The beneficial long-term effects of this 
      alternative method of training require further investigation.
FAU - Kadoglou, Nikolaos Pe
AU  - Kadoglou NP
AD  - 1 Department of Cardiology, Catharina Hospital, The Netherlands.
FAU - Mandila, Christina
AU  - Mandila C
AD  - 2 Department of Cardiology, Attikon University Hospital, Greece.
FAU - Karavidas, Apostolos
AU  - Karavidas A
AD  - 3 Department of Cardiology, General Hospital "G. Gennimatas", Greece.
FAU - Farmakis, Dimitrios
AU  - Farmakis D
AD  - 2 Department of Cardiology, Attikon University Hospital, Greece.
FAU - Matzaraki, Vasiliki
AU  - Matzaraki V
AD  - 3 Department of Cardiology, General Hospital "G. Gennimatas", Greece.
FAU - Varounis, Christos
AU  - Varounis C
AD  - 2 Department of Cardiology, Attikon University Hospital, Greece.
FAU - Arapi, Sofia
AU  - Arapi S
AD  - 3 Department of Cardiology, General Hospital "G. Gennimatas", Greece.
FAU - Perpinia, Anastasia
AU  - Perpinia A
AD  - 3 Department of Cardiology, General Hospital "G. Gennimatas", Greece.
FAU - Parissis, John
AU  - Parissis J
AD  - 2 Department of Cardiology, Attikon University Hospital, Greece.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20170112
PL  - England
TA  - Eur J Prev Cardiol
JT  - European journal of preventive cardiology
JID - 101564430
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease
MH  - Disease Progression
MH  - Electric Stimulation Therapy/adverse effects/*methods/mortality
MH  - Exercise Therapy/adverse effects/*methods/mortality
MH  - Exercise Tolerance
MH  - Female
MH  - Heart Failure/diagnosis/mortality/physiopathology/*therapy
MH  - Hospitalization
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lower Extremity
MH  - Male
MH  - Middle Aged
MH  - *Muscle Contraction
MH  - Prospective Studies
MH  - Quadriceps Muscle/*innervation
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Chronic heart failure
OT  - functional electrical stimulation
OT  - heart failure decompensation
OT  - hospitalisation
OT  - mortality
EDAT- 2017/01/13 06:00
MHDA- 2018/03/06 06:00
CRDT- 2017/01/13 06:00
PHST- 2017/01/13 06:00 [pubmed]
PHST- 2018/03/06 06:00 [medline]
PHST- 2017/01/13 06:00 [entrez]
AID - 10.1177/2047487316687428 [doi]
PST - ppublish
SO  - Eur J Prev Cardiol. 2017 May;24(8):833-839. doi: 10.1177/2047487316687428. Epub 
      2017 Jan 12.