PMID- 28079913
OWN - NLM
STAT- MEDLINE
DCOM- 20170502
LR  - 20170502
IS  - 1938-2359 (Electronic)
IS  - 0090-4481 (Linking)
VI  - 46
IP  - 1
DP  - 2017 Jan 1
TI  - Intravenous Immunoglobulin in the Treatment of Hematologic Disorders in 
      Pediatrics.
PG  - e13-e18
LID - 10.3928/19382359-20161213-01 [doi]
AB  - Intravenous immunoglobulin (IVIG) is pooled immunoglobulin G derived from human 
      blood donors. It was introduced in the early 1980s to treat immunodeficiency 
      disorders. Since then, its use has expanded to other fields such as neurology, 
      rheumatology, and hematology. IVIG has been used to provide passive immunity in 
      qualitative and quantitative immunoglobulin disorders, to neutralize antibodies 
      in immune-mediated diseases, and as an immune modulatory agent. The difficulty of 
      producing IVIG in high quantities, in addition to a growing list of "off-label" 
      indications, has resulted in a worldwide shortage and increase in cost. From a 
      pediatric hematology perspective, IVIG is considered an appropriate therapeutic 
      option in autoimmune cytopenias, sometimes coadministrated with steroids. Its use 
      in other hematologic disorders is questionable, and there is not sufficient 
      evidence to recommend it. This article provides clear information to the general 
      pediatrician about indications for IVIG therapy in children with hematologic 
      disorders. [Pediatr Ann. 2017;46(1):e13-e18.].
CI  - Copyright 2017, SLACK Incorporated.
FAU - Villanueva, Gabriela
AU  - Villanueva G
FAU - de Jong, Jill L O
AU  - de Jong JL
FAU - McNeer, Jennifer L
AU  - McNeer JL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Ann
JT  - Pediatric annals
JID - 0356657
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Child
MH  - Female
MH  - Hematologic Diseases/*therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/adverse effects/*therapeutic use
MH  - Infant
MH  - Pediatrics
MH  - Treatment Outcome
EDAT- 2017/01/13 06:00
MHDA- 2017/05/04 06:00
CRDT- 2017/01/13 06:00
PHST- 2017/01/13 06:00 [entrez]
PHST- 2017/01/13 06:00 [pubmed]
PHST- 2017/05/04 06:00 [medline]
AID - 10.3928/19382359-20161213-01 [doi]
PST - ppublish
SO  - Pediatr Ann. 2017 Jan 1;46(1):e13-e18. doi: 10.3928/19382359-20161213-01.