PMID- 28079914
OWN - NLM
STAT- MEDLINE
DCOM- 20170502
LR  - 20170502
IS  - 1938-2359 (Electronic)
IS  - 0090-4481 (Linking)
VI  - 46
IP  - 1
DP  - 2017 Jan 1
TI  - Intravenous Immunoglobulin in Pediatric Rheumatology: When to Use It and What Is 
      the Evidence.
PG  - e19-e24
LID - 10.3928/19382359-20161214-01 [doi]
AB  - Intravenous immunoglobulin (IVIG) is given to children with a variety of 
      rheumatologic illnesses. The mechanism of action by which it exerts therapeutic 
      effects is not well understood and likely differs in the medical conditions for 
      which it is given. IVIG is approved by the US Food and Drug Administration and is 
      the standard of care for Kawasaki disease, but most IVIG use in pediatric 
      rheumatology is "off-label. " The literature supports the use of IVIG for 
      juvenile dermatomyositis, although it is unclear whether its use should be 
      limited to those children with more severe or refractory disease. It appears 
      efficacious in the treatment of autoimmune thrombocytopenia secondary to lupus, 
      but its use may be limited by transient responses. Treatment of other categories 
      of pediatric rheumatologic diseases, such as juvenile idiopathic arthritis and 
      non-Kawasaki vasculitides, is not well-established in the literature. This review 
      focuses on current use of IVIG in the treatment of pediatric rheumatologic 
      disorders. [Pediatr Ann. 2017;46(1):e19-e24.].
CI  - Copyright 2017, SLACK Incorporated.
FAU - Rodriguez, Martha M
AU  - Rodriguez MM
FAU - Wagner-Weiner, Linda
AU  - Wagner-Weiner L
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Ann
JT  - Pediatric annals
JID - 0356657
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Child
MH  - Humans
MH  - Immunoglobulins, Intravenous/adverse effects/*therapeutic use
MH  - Pediatrics/methods
MH  - Rheumatic Diseases/*therapy
MH  - Rheumatology/*methods
EDAT- 2017/01/13 06:00
MHDA- 2017/05/04 06:00
CRDT- 2017/01/13 06:00
PHST- 2017/01/13 06:00 [entrez]
PHST- 2017/01/13 06:00 [pubmed]
PHST- 2017/05/04 06:00 [medline]
AID - 10.3928/19382359-20161214-01 [doi]
PST - ppublish
SO  - Pediatr Ann. 2017 Jan 1;46(1):e19-e24. doi: 10.3928/19382359-20161214-01.