PMID- 28081639
OWN - NLM
STAT- MEDLINE
DCOM- 20181026
LR  - 20181026
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 31
IP  - 3
DP  - 2018 Feb
TI  - Differential expression of cord blood neurotrophins in gestational diabetes: the 
      impact of fetal growth abnormalities.
PG  - 278-283
LID - 10.1080/14767058.2017.1281907 [doi]
AB  - OBJECTIVE: Gestational diabetes mellitus (GDM) may induce fetal macrosomia or 
      growth restriction and is associated with later offspring neurodevelopmental 
      disorders. We aimed to determine whether neurotrophins brain-derived neurotrophic 
      factor (BDNF), nerve growth factor (NGF) and neurotrophin-4 (NT-4) are 
      differentially expressed in cord blood samples at birth in 
      large-for-gestational-age (LGA), intrauterine-growth-restricted (IUGR) and 
      appropriate-for-gestational-age (AGA) offspring of diabetic mothers, as compared 
      to AGA controls from non-diabetic mothers. METHODS: BDNF, NGF and NT-4 
      concentrations were prospectively determined in 80 cord blood samples from LGA 
      (n = 15), IUGR (n = 12) and AGA (n = 33) diabetic, as well as from AGA normal 
      (controls, n = 20) singleton full-term pregnancies. RESULTS: Fetal BDNF 
      concentrations considerably decreased in GDM, as compared with normal pregnancies 
      [(b = -2.836, 95%CI -5.067 to (-0.604), p = 0.013)] and were higher in females 
      (b = 2.298, 95%CI 0.357-4.238, p = 0.021). Cord blood NGF concentrations were 
      lower in IUGR than AGA infants (p = 0.038). CONCLUSIONS: BDNF is down-regulated 
      in the fetus exposed to GDM, independently of the fetal growth pattern, probably 
      representing a candidate mechanism underlying the association between maternal 
      diabetes and later psychopathology. IUGR fetuses born to diabetic mothers present 
      with NGF deficiency, which may contribute to their long-term neurodevelopmental 
      sequelae. Gender-dependent differences in fetal BDNF may partly explain the 
      higher prevalence of adverse neurodevelopmental outcomes following brain insults 
      in male infants.
FAU - Briana, Despina D
AU  - Briana DD
AD  - a Department of Neonatology , National and Kapodistrian University of Athens , 
      Athens , Greece.
FAU - Papastavrou, Maria
AU  - Papastavrou M
AD  - a Department of Neonatology , National and Kapodistrian University of Athens , 
      Athens , Greece.
FAU - Boutsikou, Maria
AU  - Boutsikou M
AD  - a Department of Neonatology , National and Kapodistrian University of Athens , 
      Athens , Greece.
FAU - Marmarinos, Antonios
AU  - Marmarinos A
AD  - b Laboratory of Clinical Biochemistry-Molecular Diagnostics, 2nd Department of 
      Pediatrics , National and Kapodistrian University of Athens , Athens , Greece.
FAU - Gourgiotis, Dimitrios
AU  - Gourgiotis D
AD  - b Laboratory of Clinical Biochemistry-Molecular Diagnostics, 2nd Department of 
      Pediatrics , National and Kapodistrian University of Athens , Athens , Greece.
FAU - Malamitsi-Puchner, Ariadne
AU  - Malamitsi-Puchner A
AD  - a Department of Neonatology , National and Kapodistrian University of Athens , 
      Athens , Greece.
LA  - eng
PT  - Journal Article
DEP - 20170202
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Fetal Blood/metabolism
MH  - Fetal Growth Retardation/*blood
MH  - Fetal Macrosomia/*blood
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Nerve Growth Factors/*blood
MH  - Pregnancy
OTO - NOTNLM
OT  - Gestational diabetes mellitus
OT  - fetal macrosomia
OT  - intrauterine growth restriction
OT  - neurotrophins
OT  - pregnancy
EDAT- 2017/01/14 06:00
MHDA- 2018/10/27 06:00
CRDT- 2017/01/14 06:00
PHST- 2017/01/14 06:00 [pubmed]
PHST- 2018/10/27 06:00 [medline]
PHST- 2017/01/14 06:00 [entrez]
AID - 10.1080/14767058.2017.1281907 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2018 Feb;31(3):278-283. doi: 
      10.1080/14767058.2017.1281907. Epub 2017 Feb 2.