PMID- 28081733
OWN - NLM
STAT- MEDLINE
DCOM- 20170314
LR  - 20211124
IS  - 1555-3906 (Electronic)
IS  - 0965-0407 (Print)
IS  - 0965-0407 (Linking)
VI  - 25
IP  - 1
DP  - 2017 Jan 2
TI  - Tumor Necrosis Factor (TNF)-alpha-Induced Protein 8-like-2 (TIPE2) Inhibits 
      Proliferation and Tumorigenesis in Breast Cancer Cells.
PG  - 55-63
LID - 10.3727/096504016X14719078133320 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha)-induced protein 8-like-2 (TNFAIP8L2 or TIPE2), a 
      member of the tumor necrosis TNFAIP8 family, was found to be involved in the 
      development and progression of several tumors. However, to date, the role of 
      TIPE2 in breast cancer is still unclear. Thus, the aim of this study is to 
      explore the role of TIPE2 in breast cancer. Our results indicated that TIPE2 
      expression was significantly decreased in human breast cancer tissue and cell 
      lines. Overexpression of TIPE2 inhibited the proliferation in vitro and tumor 
      xenograft growth in vivo. TIPE2 also inhibited the migration/invasion of breast 
      cancer cells through preventing the epithelial-to-mesenchymal transition (EMT) 
      phenotype. Mechanically, TIPE2 inhibited the expression of beta-catenin, cyclin D1, 
      and c-Myc in breast cancer cells. In conclusion, our findings show that TIPE2 may 
      play an important role in breast cancer cell proliferation, invasion, and 
      tumorigenesis in vivo. Therefore, TIPE2 may be a potential molecular target for 
      the treatment of breast cancer.
FAU - Wang, Ke
AU  - Wang K
AD  - Department of Breast Surgery, the First Affiliated Hospital of Xian Jiaotong 
      UniversityXianP.R. China.
FAU - Ren, Yu
AU  - Ren Y
AD  - Department of Breast Surgery, the First Affiliated Hospital of Xian Jiaotong 
      UniversityXianP.R. China.
FAU - Liu, Yang
AU  - Liu Y
AD  - Department of Breast Surgery, the First Affiliated Hospital of Xian Jiaotong 
      UniversityXianP.R. China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Department of Breast Surgery, the First Affiliated Hospital of Xian Jiaotong 
      UniversityXianP.R. China.
FAU - He, Jian-Jun
AU  - He JJ
AD  - Department of Breast Surgery, the First Affiliated Hospital of Xian Jiaotong 
      UniversityXianP.R. China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncol Res
JT  - Oncology research
JID - 9208097
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (TNFAIP8L2 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/*genetics/*metabolism/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation
MH  - Cell Transformation, Neoplastic/*genetics/*metabolism
MH  - Disease Models, Animal
MH  - Epithelial-Mesenchymal Transition/genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*genetics
MH  - Mice
MH  - Signal Transduction
MH  - Tumor Burden
MH  - Tumor Necrosis Factor-alpha/*metabolism
MH  - Wnt Signaling Pathway
MH  - Xenograft Model Antitumor Assays
PMC - PMC7840691
COIS- The authors declare no conflicts of interest.
EDAT- 2017/01/14 06:00
MHDA- 2017/03/16 06:00
PMCR- 2017/01/02
CRDT- 2017/01/14 06:00
PHST- 2017/01/14 06:00 [entrez]
PHST- 2017/01/14 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
PHST- 2017/01/02 00:00 [pmc-release]
AID - OR934 [pii]
AID - 10.3727/096504016X14719078133320 [doi]
PST - ppublish
SO  - Oncol Res. 2017 Jan 2;25(1):55-63. doi: 10.3727/096504016X14719078133320.