PMID- 28082976
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231111
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 7
DP  - 2016
TI  - The Wnt Blows: On the Functional Role of Wnt Signaling in Mycobacterium 
      tuberculosis Infection and Beyond.
PG  - 635
LID - 10.3389/fimmu.2016.00635 [doi]
LID - 635
AB  - In recent years, it has become apparent that the Wnt signaling pathway, known for 
      its essential functions in embryonic development and tissue homeostasis, exerts 
      immunomodulatory functions during inflammation and infection. Most functional 
      studies indicate that Wnt5a exerts pro-inflammatory functions on its cellular 
      targets, which include various types of immune and non-immune cells. Wnt5a 
      expression has also been linked to the pathogenesis of chronic inflammatory 
      diseases. Activation of beta-catenin-dependent Wnt signaling, e.g., by Wnt3a, has 
      however been shown to limit inflammation by interfering with the nuclear factor 
      kappa-light chain-enhancer of activated B-cells (NF-kappaB) pathway. This review 
      focuses on the regulation of Wnt5a, Wnt3a, and the recently identified Wnt6 and 
      their functional role in bacterial infections with a primary focus on pulmonary 
      tuberculosis, a leading infectious cause of morbidity and mortality worldwide.
FAU - Brandenburg, Julius
AU  - Brandenburg J
AD  - Microbial Interface Biology, Priority Research Area Infections, Research Center 
      Borstel, Leibniz Center for Medicine and Biosciences , Borstel , Germany.
FAU - Reiling, Norbert
AU  - Reiling N
AD  - Microbial Interface Biology, Priority Research Area Infections, Research Center 
      Borstel, Leibniz Center for Medicine and Biosciences , Borstel , Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161226
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC5183615
OTO - NOTNLM
OT  - Mycobacterium tuberculosis
OT  - Wnt proteins
OT  - beta catenin
OT  - granuloma
OT  - inflammation
OT  - macrophages
OT  - toll-like receptors
EDAT- 2017/01/14 06:00
MHDA- 2017/01/14 06:01
PMCR- 2016/01/01
CRDT- 2017/01/14 06:00
PHST- 2016/10/15 00:00 [received]
PHST- 2016/12/12 00:00 [accepted]
PHST- 2017/01/14 06:00 [entrez]
PHST- 2017/01/14 06:00 [pubmed]
PHST- 2017/01/14 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2016.00635 [doi]
PST - epublish
SO  - Front Immunol. 2016 Dec 26;7:635. doi: 10.3389/fimmu.2016.00635. eCollection 
      2016.