PMID- 28083985
OWN - NLM
STAT- MEDLINE
DCOM- 20180606
LR  - 20180821
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Linking)
VI  - 89
IP  - 3
DP  - 2017 Mar
TI  - HLA-G regulatory polymorphisms are associated with susceptibility to HCV 
      infection.
PG  - 135-142
LID - 10.1111/tan.12959 [doi]
AB  - BACKGROUND: Hepatitis C virus (HCV) is able to bypass the immune system 
      modulating innate and adaptive immune response and blocking T helper 1 (Th1) cell 
      production. Because the human leukocyte antigen (HLA)-G molecule has 
      immunomodulatory properties inhibiting the function and production of natural 
      killer and cytotoxic lymphocyte T cells, as well as promoting shift from Th1 
      toward Th2 response, we hypothesized its involvement in susceptibility to HCV 
      infection. MATERIALS AND METHODS: Considering that HLA-G mRNA expression has been 
      reported to be under genetic control, an association study was conducted 
      analyzing 800 base pairs upstream the ATG at the 5'upstream regulator region 
      (URR) and 850 base pairs from ATG to exon 3 and the 3'untranslated region (UTR) 
      of HLA-G gene in Italian HCV-positive patients and uninfected controls. RESULTS: 
      Four 5'URR polymorphisms (-725C>G>T, -509C>G, -400G>A and -398G>A), 7 
      polymorphisms at coding region (+15G>A, +36G>A, +243G>A, insC506, 531G>C, delA615 
      and 685G>A), the +644G>T polymorphism, and 1 haplotype (TTGTTCCIGAC) showed 
      different frequency distributions between HCV patients and uninfected controls. 
      CONCLUSION: The results from our study suggest a possible involvement of HLA-G in 
      the risk modulation toward HCV infection.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Catamo, E
AU  - Catamo E
AD  - Department of Medicine, Surgery and Health Sciences, University of Trieste, 
      Trieste, Italy.
FAU - Zupin, L
AU  - Zupin L
AD  - Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
FAU - Freato, N
AU  - Freato N
AD  - Department of Life Science, University of Trieste, Trieste, Italy.
FAU - Polesello, V
AU  - Polesello V
AD  - Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
FAU - Celsi, F
AU  - Celsi F
AUID- ORCID: 0000-0002-9760-8463
AD  - Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
FAU - Croce, S L
AU  - Croce SL
AD  - Department of Medicine, Surgery and Health Sciences, University of Trieste, 
      Trieste, Italy.
FAU - Masutti, F
AU  - Masutti F
AD  - Department of Medicine, Surgery and Health Sciences, University of Trieste, 
      Trieste, Italy.
FAU - Pozzato, G
AU  - Pozzato G
AD  - Department of Medicine, Surgery and Health Sciences, University of Trieste, 
      Trieste, Italy.
FAU - Segat, L
AU  - Segat L
AD  - Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
FAU - Crovella, S
AU  - Crovella S
AD  - Department of Medicine, Surgery and Health Sciences, University of Trieste, 
      Trieste, Italy.
AD  - Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170113
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (3' Untranslated Regions)
RN  - 0 (5' Untranslated Regions)
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - 3' Untranslated Regions
MH  - 5' Untranslated Regions
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Case-Control Studies
MH  - Exons
MH  - Female
MH  - Gene Expression
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-G Antigens/*genetics/immunology
MH  - Haplotypes
MH  - Hepacivirus/*immunology
MH  - Hepatitis C/diagnosis/*genetics/immunology/virology
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Risk
MH  - Th1 Cells/immunology/virology
OTO - NOTNLM
OT  - hepatitis C virus
OT  - human leukocyte antigen-G
OT  - immunity
OT  - single nucleotide polymorphism
EDAT- 2017/01/14 06:00
MHDA- 2018/06/07 06:00
CRDT- 2017/01/14 06:00
PHST- 2016/08/31 00:00 [received]
PHST- 2016/11/23 00:00 [revised]
PHST- 2016/12/21 00:00 [accepted]
PHST- 2017/01/14 06:00 [pubmed]
PHST- 2018/06/07 06:00 [medline]
PHST- 2017/01/14 06:00 [entrez]
AID - 10.1111/tan.12959 [doi]
PST - ppublish
SO  - HLA. 2017 Mar;89(3):135-142. doi: 10.1111/tan.12959. Epub 2017 Jan 13.