PMID- 2808689
OWN - NLM
STAT- MEDLINE
DCOM- 19891219
LR  - 20220410
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 24
IP  - 3
DP  - 1989 Oct
TI  - Relationship of microglia and astrocytes to amyloid deposits of Alzheimer 
      disease.
PG  - 173-82
AB  - The relationship of microglia and astrocytes to deposits of beta-amyloid protein 
      (BAP) was studied in Alzheimer's disease by immunohistochemistry. BAP was 
      detected in forms varying from diffuse amorphous deposits to compact spherical 
      masses. These latter corresponded in frequency and distribution to senile plaques 
      revealed by Bielschowsky and thioflavine S staining. Approximately half the 
      diffuse deposits had no human leukocyte antigen (HLA)-DR-positive reactive 
      microglia associated with them while nearly all compact deposits had single or 
      multiple HLA-DR-positive reactive microglia embedded in their core. Electron 
      microscopy showed these reactive microglia to be in intimate contact with amyloid 
      fibrils. These data suggest that amyloid deposition may precede the activation of 
      microglia.
FAU - Itagaki, S
AU  - Itagaki S
AD  - University of British Columbia, Department of Psychiatry, Kinsmen Laboratory of 
      Neurological Research, Vancouver, Canada.
FAU - McGeer, P L
AU  - McGeer PL
FAU - Akiyama, H
AU  - Akiyama H
FAU - Zhu, S
AU  - Zhu S
FAU - Selkoe, D
AU  - Selkoe D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*metabolism
MH  - Amyloidosis/*metabolism/pathology
MH  - Astrocytes/*metabolism/ultrastructure
MH  - Female
MH  - HLA-DR Antigens/analysis
MH  - Hippocampus/metabolism/ultrastructure
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Microscopy, Electron/methods
MH  - Neuroglia/*metabolism/ultrastructure
EDAT- 1989/10/01 00:00
MHDA- 2000/06/01 09:00
CRDT- 1989/10/01 00:00
PHST- 1989/10/01 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1989/10/01 00:00 [entrez]
AID - 0165-5728(89)90115-X [pii]
AID - 10.1016/0165-5728(89)90115-x [doi]
PST - ppublish
SO  - J Neuroimmunol. 1989 Oct;24(3):173-82. doi: 10.1016/0165-5728(89)90115-x.