PMID- 28087314
OWN - NLM
STAT- MEDLINE
DCOM- 20180220
LR  - 20191210
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 69
DP  - 2017 Apr
TI  - A protective role of cumulus cells after short-term exposure of rat cumulus 
      cell-oocyte complexes to lifestyle or environmental contaminants.
PG  - 19-33
LID - S0890-6238(16)30419-1 [pii]
LID - 10.1016/j.reprotox.2017.01.003 [doi]
AB  - Ovarian follicular fluid provides a potential reservoir for exogenous compounds 
      that may adversely affect oocyte quality. This study examined the effects of 
      common lifestyle and environmental contaminants, namely bisphenol-A (BPA), 
      caffeine, 3,4-methylenedioxymethamphetamine (MDMA), nicotine and 
      Delta(9)-tetrahydrocannabinol (THC) on gap junction genes (Gja1, Gja4) and proteins 
      (GJA1), glucose metabolism genes (Gfpt1, Pfkp) and oocyte growth factor genes 
      (Bmp15, Gdf9), as well as gap junction transfer rate, in rat cumulus-oocyte 
      complexes (COCs). In vitro exposure to MDMA and THC accelerated the timing of 
      meiotic resumption and all contaminants altered either gap junction gene 
      expression (BPA, caffeine, MDMA and THC) or transfer rate (BPA and nicotine). In 
      vitro exposure of COCs to MDMA also altered glucose metabolism genes. Overall, 
      oocyte-derived genes were largely unaffected following exposure to any 
      contaminant. In summary, the impact of short-term exposure to lifestyle and 
      environmental contaminants on oocyte function may be diminished due to protective 
      properties of cumulus cells.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Campen, Kelly A
AU  - Campen KA
AD  - School of Biological Sciences, Victoria University of Wellington, PO Box 600, 
      Wellington 6140, New Zealand.
FAU - McNatty, Kenneth P
AU  - McNatty KP
AD  - School of Biological Sciences, Victoria University of Wellington, PO Box 600, 
      Wellington 6140, New Zealand.
FAU - Pitman, Janet L
AU  - Pitman JL
AD  - School of Biological Sciences, Victoria University of Wellington, PO Box 600, 
      Wellington 6140, New Zealand. Electronic address: janet.pitman@vuw.ac.nz.
LA  - eng
PT  - Journal Article
DEP - 20170110
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Illicit Drugs)
RN  - 0 (Phenols)
RN  - 3G6A5W338E (Caffeine)
RN  - 6M3C89ZY6R (Nicotine)
RN  - 7J8897W37S (Dronabinol)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Benzhydryl Compounds/toxicity
MH  - Caffeine/toxicity
MH  - Cells, Cultured
MH  - Cumulus Cells/*drug effects/metabolism
MH  - Dronabinol/toxicity
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Illicit Drugs/*toxicity
MH  - Life Style
MH  - N-Methyl-3,4-methylenedioxyamphetamine/toxicity
MH  - Nicotine/toxicity
MH  - Oocytes/*drug effects/metabolism
MH  - Phenols/toxicity
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Cumulus cells
OT  - Environmental contaminants
OT  - Gap junctions
OT  - Glucose metabolism
OT  - Lifestyle factors
OT  - Oocyte
OT  - Oocyte growth factors
EDAT- 2017/01/15 06:00
MHDA- 2018/02/21 06:00
CRDT- 2017/01/15 06:00
PHST- 2016/11/15 00:00 [received]
PHST- 2017/01/05 00:00 [accepted]
PHST- 2017/01/15 06:00 [pubmed]
PHST- 2018/02/21 06:00 [medline]
PHST- 2017/01/15 06:00 [entrez]
AID - S0890-6238(16)30419-1 [pii]
AID - 10.1016/j.reprotox.2017.01.003 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2017 Apr;69:19-33. doi: 10.1016/j.reprotox.2017.01.003. Epub 2017 
      Jan 10.