PMID- 28087448
OWN - NLM
STAT- MEDLINE
DCOM- 20170421
LR  - 20220321
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 97
DP  - 2017 Apr
TI  - Fabrication and characterization of electrospun cellulose/nano-hydroxyapatite 
      nanofibers for bone tissue engineering.
PG  - 568-573
LID - S0141-8130(16)31772-X [pii]
LID - 10.1016/j.ijbiomac.2016.12.091 [doi]
AB  - Nanofibrous scaffolds from cotton cellulose and nano-hydroxyapatite (nano-HA) 
      were electrospun for bone tissue engineering. The solution properties of 
      cellulose/nano-HA spinning dopes and their associated electrospinnability were 
      characterized. Morphological, thermal and mechanical properties of the 
      electrospun cellulose/nano-HA nanocomposite nanofibers (ECHNN) were measured and 
      the biocompatibility of ECHNN with human dental follicle cells (HDFCs) was 
      evaluated. Scanning electron microscope (SEM) images indicated that the average 
      diameter of ECHNN increased with a higher nano-HA loading and the fiber diameter 
      distributions were well within the range of natural ECM (extra cellular matrix) 
      fibers (50-500nm). The ECHNN exhibited extraordinary mechanical properties with a 
      tensile strength and a Young's modulus up to 70.6MPa and 3.12GPa respectively. 
      Moreover, it was discovered that the thermostability of the ECHNN could be 
      enhanced with the incorporation of nano-HA. Cell culture experiments demonstrated 
      that the ECHNN scaffolds were quite biocompatible for HDFCs attachment and 
      proliferation, suggesting their great potentials as scaffold materials in bone 
      tissue engineering.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Ao, Chenghong
AU  - Ao C
AD  - State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute 
      at Sichuan University, Chengdu 610065, China.
FAU - Niu, Yan
AU  - Niu Y
AD  - State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute 
      at Sichuan University, Chengdu 610065, China.
FAU - Zhang, Ximu
AU  - Zhang X
AD  - State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan 
      University, Chengdu 610041, China.
FAU - He, Xu
AU  - He X
AD  - State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute 
      at Sichuan University, Chengdu 610065, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute 
      at Sichuan University, Chengdu 610065, China. Electronic address: 
      weizhang@scu.edu.cn.
FAU - Lu, Canhui
AU  - Lu C
AD  - State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute 
      at Sichuan University, Chengdu 610065, China. Electronic address: 
      canhuilu@263.net.
LA  - eng
PT  - Journal Article
DEP - 20170110
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Biocompatible Materials)
RN  - 9004-34-6 (Cellulose)
RN  - 91D9GV0Z28 (Durapatite)
SB  - IM
MH  - Biocompatible Materials/*chemistry/pharmacology
MH  - Cell Adhesion/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cellulose/*chemistry
MH  - Dental Sac/cytology
MH  - Durapatite/*chemistry
MH  - *Electricity
MH  - Humans
MH  - Mechanical Phenomena
MH  - Nanofibers/*chemistry
MH  - *Tissue Engineering
MH  - Tissue Scaffolds/*chemistry
OTO - NOTNLM
OT  - Bone tissue engineering
OT  - Cotton cellulose
OT  - Electrospinning
EDAT- 2017/01/15 06:00
MHDA- 2017/04/22 06:00
CRDT- 2017/01/15 06:00
PHST- 2016/09/26 00:00 [received]
PHST- 2016/12/30 00:00 [accepted]
PHST- 2017/01/15 06:00 [pubmed]
PHST- 2017/04/22 06:00 [medline]
PHST- 2017/01/15 06:00 [entrez]
AID - S0141-8130(16)31772-X [pii]
AID - 10.1016/j.ijbiomac.2016.12.091 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2017 Apr;97:568-573. doi: 10.1016/j.ijbiomac.2016.12.091. 
      Epub 2017 Jan 10.