PMID- 28087683
OWN - NLM
STAT- MEDLINE
DCOM- 20170627
LR  - 20220409
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 139
IP  - 2
DP  - 2017 Feb
TI  - Percutaneous Patent Ductus Arteriosus (PDA) Closure During Infancy: A 
      Meta-analysis.
LID - e20162927 [pii]
LID - 10.1542/peds.2016-2927 [doi]
AB  - CONTEXT: Patent ductus arteriosus (PDA) is a precursor to morbidity and 
      mortality. Percutaneous (catheter-based) closure is the procedure of choice for 
      adults and older children with a PDA, but use during infancy (<1 year) is not 
      well characterized. OBJECTIVE: Investigate the technical success and safety of 
      percutaneous PDA closure during infancy. DATA SOURCES: Scopus, Web of Science, 
      Embase, PubMed, and Ovid (Medline) were searched through December 2015 with no 
      language restrictions. STUDY SELECTION: Publications needed to clearly define the 
      intervention as percutaneous PDA closure during infancy (<1 year of age at 
      intervention) and must have reported adverse events (AEs). DATA EXTRACTION: The 
      study was performed according to the Systematic Reviews and Meta-Analysis 
      checklist and registered prospectively. The quality of the selected studies was 
      critically examined. Data extraction and assignment of AE attributability and 
      severity were independently performed by multiple observers. Outcomes were agreed 
      on a priori. Data were pooled by using a random-effects model. RESULTS: 
      Thirty-eight studies were included; no randomized controlled trials were found. 
      Technical success of percutaneous PDA closure was 92.2% (95% confidence interval 
      [CI] 88.8-95.0). Overall AE and clinically significant AE incidence was 23.3% 
      (95% CI 16.5-30.8) and 10.1% (95% CI 7.8-12.5), respectively. Significant 
      heterogeneity and publication bias were observed. LIMITATIONS: Limitations 
      include lack of comparative studies, lack of standardized AE reporting strategy, 
      and significant heterogeneity in reporting. CONCLUSIONS: Percutaneous PDA closure 
      during infancy is feasible and associated with few catastrophic AEs; however, the 
      limitations constrain the interpretability and generalizability of the current 
      findings.
CI  - Copyright (c) 2017 by the American Academy of Pediatrics.
FAU - Backes, Carl H
AU  - Backes CH
AD  - Centers for Perinatal Research, carl.backesjr@nationwidechildrens.org.
AD  - Cardiovascular and Pulmonary Research, and.
AD  - The Heart Center, The Research Institute at Nationwide Children's Hospital, 
      Nationwide Children's Hospital, Columbus, Ohio.
AD  - Department of Pediatrics, The Ohio State University, Columbus, Ohio.
FAU - Rivera, Brian K
AU  - Rivera BK
AD  - Centers for Perinatal Research.
FAU - Bridge, Jeffrey A
AU  - Bridge JA
AD  - Department of Pediatrics, The Ohio State University, Columbus, Ohio.
AD  - Innovation in Pediatric Practice, and.
FAU - Armstrong, Aimee K
AU  - Armstrong AK
AD  - Cardiovascular and Pulmonary Research, and.
AD  - The Heart Center, The Research Institute at Nationwide Children's Hospital, 
      Nationwide Children's Hospital, Columbus, Ohio.
AD  - Department of Pediatrics, The Ohio State University, Columbus, Ohio.
FAU - Boe, Brian A
AU  - Boe BA
AD  - Cardiovascular and Pulmonary Research, and.
AD  - The Heart Center, The Research Institute at Nationwide Children's Hospital, 
      Nationwide Children's Hospital, Columbus, Ohio.
AD  - Department of Pediatrics, The Ohio State University, Columbus, Ohio.
FAU - Berman, Darren P
AU  - Berman DP
AD  - Cardiovascular and Pulmonary Research, and.
AD  - The Heart Center, The Research Institute at Nationwide Children's Hospital, 
      Nationwide Children's Hospital, Columbus, Ohio.
AD  - Department of Pediatrics, The Ohio State University, Columbus, Ohio.
FAU - Fick, Tyler
AU  - Fick T
AD  - Department of Pediatrics, The Ohio State University, Columbus, Ohio.
FAU - Holzer, Ralf J
AU  - Holzer RJ
AD  - Department of Pediatrics, Weill Cornell Medical College, New York, New York.
AD  - Cardiac Catheterization and Interventional Therapy, Sidra Cardiac Program, Sidra 
      Medical and Research Center, Doha, Qatar.
FAU - Hijazi, Ziyad M
AU  - Hijazi ZM
AD  - Department of Pediatrics, Weill Cornell Medical College, New York, New York.
AD  - Cardiac Catheterization and Interventional Therapy, Sidra Cardiac Program, Sidra 
      Medical and Research Center, Doha, Qatar.
FAU - Abadir, Sylvia
AU  - Abadir S
AD  - Department of Pediatric Cardiology, CHU mere-enfant Sainte-Justine, Universite de 
      Montreal, Quebec, Canada.
FAU - Justino, Henri
AU  - Justino H
AD  - Section of Pediatric Cardiology, Texas Children's Hospital, Baylor College of 
      Medicine, Houston, Texas.
FAU - Bergersen, Lisa
AU  - Bergersen L
AD  - Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts.
FAU - Smith, Charles V
AU  - Smith CV
AD  - Center for Developmental Therapeutics, Seattle Children's Research Institute, 
      University of Washington School of Medicine, Seattle, Washington; and.
FAU - Kirpalani, Haresh
AU  - Kirpalani H
AD  - Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, 
      Pennsylvania.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20170113
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Cardiac Catheterization/adverse effects/*methods
MH  - Clinical Studies as Topic
MH  - Ductus Arteriosus, Patent/*therapy
MH  - Embolization, Therapeutic/instrumentation
MH  - Feasibility Studies
MH  - Humans
MH  - Infant
MH  - Safety
MH  - Septal Occluder Device
MH  - Treatment Outcome
EDAT- 2017/01/15 06:00
MHDA- 2017/06/28 06:00
CRDT- 2017/01/15 06:00
PHST- 2016/10/31 00:00 [accepted]
PHST- 2017/01/15 06:00 [pubmed]
PHST- 2017/06/28 06:00 [medline]
PHST- 2017/01/15 06:00 [entrez]
AID - peds.2016-2927 [pii]
AID - 10.1542/peds.2016-2927 [doi]
PST - ppublish
SO  - Pediatrics. 2017 Feb;139(2):e20162927. doi: 10.1542/peds.2016-2927. Epub 2017 Jan 
      13.