PMID- 28088017
OWN - NLM
STAT- MEDLINE
DCOM- 20170321
LR  - 20220330
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 152
DP  - 2017 Apr 1
TI  - Co-delivery of ibuprofen and gentamicin from nanoporous anodic titanium dioxide 
      layers.
PG  - 95-102
LID - S0927-7765(17)30019-X [pii]
LID - 10.1016/j.colsurfb.2017.01.011 [doi]
AB  - Although single-drug therapy may prove insufficient in treating bacterial 
      infections or inflammation after orthopaedic surgeries, complex therapy (using 
      both an antibiotic and an anti-inflammatory drug) is thought to address the 
      problem. Among drug delivery systems (DDSs) with prolonged drug release profiles, 
      nanoporous anodic titanium dioxide (ATO) layers on Ti foil are very promising. In 
      the discussed research, ATO samples were synthesized via a three-step anodization 
      process in an ethylene glycol-based electrolyte with fluoride ions. The third 
      step lasted 2, 5 and 10min in order to obtain different thicknesses of nanoporous 
      layers. Annealing the as-prepared amorphous layers at the temperature of 400 degrees C 
      led to obtaining the anatase phase. In this study, water-insoluble ibuprofen and 
      water-soluble gentamicin were used as model drugs. Three different drug loading 
      procedures were applied. The desorption-desorption-diffusion (DDD) model of the 
      drug release was fitted to the experimental data. The effects of crystalline 
      structure, depth of TiO(2) nanopores and loading procedure on the drug release 
      profiles were examined. The duration of the drug release process can be easily 
      altered by changing the drug loading sequence. Water-soluble gentamicin is 
      released for a long period of time if gentamicin is loaded in ATO as the first 
      drug. Additionally, deeper nanopores and anatase phase suppress the initial burst 
      release of drugs. These results confirm that factors such as morphological and 
      crystalline structure of ATO layers, and the procedure of drug loading inside 
      nanopores, allow to alter the drug release performance of nanoporous ATO layers.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Pawlik, Anna
AU  - Pawlik A
AD  - Department of Physical Chemistry and Electrochemistry, Faculty of Chemistry, 
      Jagiellonian University in Krakow, Ingardena 3, 30060 Krakow, Poland.
FAU - Jarosz, Magdalena
AU  - Jarosz M
AD  - Department of Physical Chemistry and Electrochemistry, Faculty of Chemistry, 
      Jagiellonian University in Krakow, Ingardena 3, 30060 Krakow, Poland.
FAU - Syrek, Karolina
AU  - Syrek K
AD  - Department of Physical Chemistry and Electrochemistry, Faculty of Chemistry, 
      Jagiellonian University in Krakow, Ingardena 3, 30060 Krakow, Poland.
FAU - Sulka, Grzegorz D
AU  - Sulka GD
AD  - Department of Physical Chemistry and Electrochemistry, Faculty of Chemistry, 
      Jagiellonian University in Krakow, Ingardena 3, 30060 Krakow, Poland. Electronic 
      address: sulka@chemia.uj.edu.pl.
LA  - eng
PT  - Journal Article
DEP - 20170108
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Gentamicins)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
MH  - Gentamicins/*chemistry
MH  - Ibuprofen/*chemistry
MH  - Nanoparticles/*chemistry
MH  - Nanopores
MH  - Nanotubes/chemistry
MH  - Porosity
MH  - Titanium/*chemistry
OTO - NOTNLM
OT  - Anodization
OT  - Co-delivery
OT  - Gentamicin
OT  - Ibuprofen
OT  - Nanoporous titanium dioxide
OT  - TiO(2) nanotubes
EDAT- 2017/01/15 06:00
MHDA- 2017/03/23 06:00
CRDT- 2017/01/15 06:00
PHST- 2016/10/04 00:00 [received]
PHST- 2016/12/11 00:00 [revised]
PHST- 2017/01/06 00:00 [accepted]
PHST- 2017/01/15 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
PHST- 2017/01/15 06:00 [entrez]
AID - S0927-7765(17)30019-X [pii]
AID - 10.1016/j.colsurfb.2017.01.011 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2017 Apr 1;152:95-102. doi: 
      10.1016/j.colsurfb.2017.01.011. Epub 2017 Jan 8.