PMID- 28088080
OWN - NLM
STAT- MEDLINE
DCOM- 20171204
LR  - 20180420
IS  - 1879-0534 (Electronic)
IS  - 0010-4825 (Linking)
VI  - 81
DP  - 2017 Feb 1
TI  - A computer-based simulator for intravascular photoacoustic images.
PG  - 176-187
LID - S0010-4825(17)30002-1 [pii]
LID - 10.1016/j.compbiomed.2017.01.002 [doi]
AB  - Intravascular photoacoustic (IVPA) is a newly developed catheter-based imaging 
      technique for the diagnosis of arterial atherosclerosis. A framework of 
      simulating IVPA transversal images from a cross-sectional vessel model with given 
      optical and acoustic parameters was presented. The light illumination and 
      transportation in multi-layered wall and atherosclerotic plaque tissues were 
      modeled through Monte Carlo (MC) simulation. The generation and transmission of 
      photoacoustic (PA) waves in the acoustically homogeneous medium were modeled 
      through the PA wave equation, which is solved explicitly with a finite difference 
      time domain (FDTD) algorithm in polar coordinates. Finally, a series of 
      cross-sectional gray-scale images displaying the distribution of the deposited 
      optical energy were reconstructed from the time-dependent acoustic pressure 
      series with a time-reversal based algorithm. Experimental results demonstrate a 
      good correlation between the simulated IVPA images and the optical absorption 
      distribution profiles. The simulator provides a powerful tool for generating IVPA 
      image data sets, which are used to improve the imaging catheter and to test the 
      performance of image post-processing algorithms.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Zheng, Sun
AU  - Zheng S
AD  - Department of Electronic and Communication Engineering, North China Electric 
      Power University, Baoding 071003, Hebei, China. Electronic address: 
      sunzheng_tju@163.com.
FAU - Yuan, Yuan
AU  - Yuan Y
AD  - Department of Electronic and Communication Engineering, North China Electric 
      Power University, Baoding 071003, Hebei, China.
FAU - Duoduo, Han
AU  - Duoduo H
AD  - Department of Electronic and Communication Engineering, North China Electric 
      Power University, Baoding 071003, Hebei, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170106
PL  - United States
TA  - Comput Biol Med
JT  - Computers in biology and medicine
JID - 1250250
SB  - IM
MH  - *Algorithms
MH  - Computer Simulation
MH  - Coronary Artery Disease/*diagnostic imaging/physiopathology
MH  - Coronary Vessels/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Models, Cardiovascular
MH  - *Models, Statistical
MH  - Photoacoustic Techniques/*methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Ultrasonography, Interventional/*methods
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Coronary artery
OT  - Image simulator
OT  - Intravascular photoacoustic (IVPA)
OT  - Numerical simulation
OT  - Photoacoustic imaging
EDAT- 2017/01/15 06:00
MHDA- 2017/12/05 06:00
CRDT- 2017/01/15 06:00
PHST- 2016/09/19 00:00 [received]
PHST- 2017/01/05 00:00 [revised]
PHST- 2017/01/05 00:00 [accepted]
PHST- 2017/01/15 06:00 [pubmed]
PHST- 2017/12/05 06:00 [medline]
PHST- 2017/01/15 06:00 [entrez]
AID - S0010-4825(17)30002-1 [pii]
AID - 10.1016/j.compbiomed.2017.01.002 [doi]
PST - ppublish
SO  - Comput Biol Med. 2017 Feb 1;81:176-187. doi: 10.1016/j.compbiomed.2017.01.002. 
      Epub 2017 Jan 6.