PMID- 28088391
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20180317
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 130
DP  - 2017 Apr
TI  - Changes in the cerebellar and cerebro-cerebellar circuit in type 2 diabetes.
PG  - 95-100
LID - S0361-9230(17)30017-5 [pii]
LID - 10.1016/j.brainresbull.2017.01.009 [doi]
AB  - Currently, 422 million adults suffer from diabetes worldwide, leading to 
      tremendous disabilities and a great burden to families and society. Functional 
      and structural MRIs have demonstrated that patients with type 2 diabetes mellitus 
      (T2DM) exhibit abnormalities in brain regions in the cerebral cortex. However, 
      the changes of cerebellar anatomical connections in diabetic patients remains 
      unclear. In the current study, diffusion tensor imaging deterministic 
      tractography and statistical analysis were employed to investigate abnormal 
      cerebellar anatomical connections in diabetic patients. This is the first study 
      to investigate the altered cerebellar anatomical connectivity in T2DM patients. 
      Decreased anatomical connections were found in the cerebellar and 
      cerebro-cerebellar circuits of T2DM patients, providing valuable new insights 
      into the potential neuro-pathophysiology of diabetes-related motor and cognitive 
      deficits.
CI  - Copyright (c) 2017. Published by Elsevier Inc.
FAU - Fang, Peng
AU  - Fang P
AD  - College of Mechatronics and Automation, National University of Defense 
      Technology, Changsha, Hunan, 410073, China.
FAU - An, Jie
AU  - An J
AD  - Department of Medical Imaging, The First Affiliated Hospital of Guangzhou 
      University of Chinese Traditional Medicine, Guangzhou, Guangdong, 510405, China.
FAU - Tan, Xin
AU  - Tan X
AD  - Department of Medical Imaging, The First Affiliated Hospital of Guangzhou 
      University of Chinese Traditional Medicine, Guangzhou, Guangdong, 510405, China.
FAU - Zeng, Ling-Li
AU  - Zeng LL
AD  - College of Mechatronics and Automation, National University of Defense 
      Technology, Changsha, Hunan, 410073, China.
FAU - Shen, Hui
AU  - Shen H
AD  - College of Mechatronics and Automation, National University of Defense 
      Technology, Changsha, Hunan, 410073, China.
FAU - Qiu, Shijun
AU  - Qiu S
AD  - Department of Medical Imaging, The First Affiliated Hospital of Guangzhou 
      University of Chinese Traditional Medicine, Guangzhou, Guangdong, 510405, China. 
      Electronic address: qiu-sj@163.com.
FAU - Hu, Dewen
AU  - Hu D
AD  - College of Mechatronics and Automation, National University of Defense 
      Technology, Changsha, Hunan, 410073, China. Electronic address: dwhu@nudt.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170111
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
SB  - IM
MH  - Brain/diagnostic imaging/*pathology
MH  - Cerebellum/diagnostic imaging/*pathology
MH  - Diabetes Mellitus, Type 2/diagnostic imaging/*pathology
MH  - Diffusion Magnetic Resonance Imaging
MH  - Diffusion Tensor Imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/diagnostic imaging/pathology
OTO - NOTNLM
OT  - Cerebellar circuit
OT  - Cerebro-cerebellar circuit
OT  - Diffusion tensor imaging
OT  - Motor and cognitive deficit
OT  - Type 2 diabetes
EDAT- 2017/01/16 06:00
MHDA- 2018/02/23 06:00
CRDT- 2017/01/16 06:00
PHST- 2016/07/13 00:00 [received]
PHST- 2016/12/21 00:00 [revised]
PHST- 2017/01/09 00:00 [accepted]
PHST- 2017/01/16 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
PHST- 2017/01/16 06:00 [entrez]
AID - S0361-9230(17)30017-5 [pii]
AID - 10.1016/j.brainresbull.2017.01.009 [doi]
PST - ppublish
SO  - Brain Res Bull. 2017 Apr;130:95-100. doi: 10.1016/j.brainresbull.2017.01.009. 
      Epub 2017 Jan 11.