PMID- 28088914
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20181113
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Print)
IS  - 1570-159X (Linking)
VI  - 15
IP  - 6
DP  - 2017
TI  - Diverse Functions and Mechanisms of Pericytes in Ischemic Stroke.
PG  - 892-905
LID - 10.2174/1570159X15666170112170226 [doi]
AB  - BACKGROUND: Every year, strokes take millions of lives and leave millions of 
      individuals living with permanent disabilities. Recently more researchers embrace 
      the concept of the neurovascular unit (NVU), which encompasses neurons, 
      endothelial cells (ECs), pericytes, astrocyte, microglia, and the extracellular 
      matrix. It has been well-documented that NVU emerged as a new paradigm for the 
      exploration of mechanisms and therapies in ischemic stroke. To better understand 
      the complex NVU and broaden therapeutic targets, we must probe the roles of 
      multiple cell types in ischemic stroke. The aims of this paper are to introduce 
      the biological characteristics of brain pericytes and the available evidence on 
      the diverse functions and mechanisms involving the pericytes in the context of 
      ischemic stroke. METHODS: Research and online content related to the biological 
      characteristics and pathophysiological roles of pericytes is review. The new 
      research direction on the Pericytes in ischemic stroke, and the potential 
      therapeutic targets are provided. RESULTS: During the different stages of 
      ischemic stroke, pericytes play different roles: 1) On the hyperacute phase of 
      stroke, pericytes constriction and death may be a cause of the no-reflow 
      phenomenon in brain capillaries; 2) During the acute phase, pericytes detach from 
      microvessels and participate in inflammatory-immunological response, resulting in 
      the BBB damage and brain edema. Pericytes also provide benefit for 
      neuroprotection by protecting endothelium, stabilizing BBB and releasing 
      neurotrophins; 3) Similarly, during the later recovery phase of stroke, pericytes 
      also contribute to angiogenesis, neurogenesis, and thereby promote neurological 
      recovery. CONCLUSION: This emphasis on the NVU concept has shifted the focus of 
      ischemic stroke research from neuro-centric views to the complex interactions 
      within NVU. With this new perspective, pericytes that are centrally positioned in 
      the NVU have been widely studied in ischemic stroke. More work is needed to 
      elucidate the beneficial and detrimental roles of brain pericytes in ischemic 
      stroke that may serve as a basis for potential therapeutic targets.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Yang, Shuai
AU  - Yang S
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Jin, Huijuan
AU  - Jin H
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Zhu, Yiyi
AU  - Zhu Y
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Wan, Yan
AU  - Wan Y
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Opoku, Elvis Nana
AU  - Opoku EN
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Zhu, Lingqiang
AU  - Zhu L
AD  - Department of Pathophysiology, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, China.
FAU - Hu, Bo
AU  - Hu B
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
SB  - IM
MH  - Animals
MH  - Brain/drug effects/physiopathology
MH  - Brain Ischemia/drug therapy/*physiopathology
MH  - Humans
MH  - Pericytes/*physiology/ultrastructure
MH  - Stroke/drug therapy/*physiopathology
PMC - PMC5652032
OTO - NOTNLM
OT  - BBB
OT  - NVU
OT  - Pericytes
OT  - ischemic stroke
OT  - mechanisms
OT  - therapeutic targets
EDAT- 2017/01/17 06:00
MHDA- 2018/04/24 06:00
PMCR- 2018/02/01
CRDT- 2017/01/17 06:00
PHST- 2016/10/05 00:00 [received]
PHST- 2016/11/30 00:00 [revised]
PHST- 2016/12/28 00:00 [accepted]
PHST- 2017/01/17 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
PHST- 2017/01/17 06:00 [entrez]
PHST- 2018/02/01 00:00 [pmc-release]
AID - CN-EPUB-81020 [pii]
AID - CN-15-892 [pii]
AID - 10.2174/1570159X15666170112170226 [doi]
PST - ppublish
SO  - Curr Neuropharmacol. 2017;15(6):892-905. doi: 10.2174/1570159X15666170112170226.