PMID- 28091126
OWN - NLM
STAT- MEDLINE
DCOM- 20171013
LR  - 20220331
IS  - 1547-6901 (Electronic)
IS  - 1547-691X (Print)
IS  - 1547-691X (Linking)
VI  - 14
IP  - 1
DP  - 2017 Dec
TI  - Association between perfluoroalkyl substance exposure and asthma and allergic 
      disease in children as modified by MMR vaccination.
PG  - 39-49
LID - 10.1080/1547691X.2016.1254306 [doi]
AB  - Perfluoroalkyl substances (PFASs) are highly persistent chemicals that might be 
      associated with asthma and allergy, but the associations remain unclear. 
      Therefore, this study examined whether pre- and postnatal PFAS exposure was 
      associated with childhood asthma and allergy. Measles, mumps, and rubella (MMR) 
      vaccination in early life may have a protective effect against asthma and 
      allergy, and MMR vaccination is therefore taken into account when evaluating 
      these associations. In a cohort of Faroese children whose mothers were recruited 
      during pregnancy, serum concentrations of five PFASs - Perfluorohexane sulfonic 
      acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid 
      (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) - were 
      measured at three timepoints (maternal serum in pregnancy week 34-36 and child 
      serum at ages 5 and 13 years) and their association with immunoglobulin E (IgE) 
      (cord blood and at age 7 years) and asthma/allergic diseases (questionnaires at 
      ages 5 and 13 years and skin prick test at age 13 years) was determined. A total 
      of 559 children were included in the analyses. Interactions with MMR vaccination 
      were evaluated. Among 22 MMR-unvaccinated children, higher levels of the five 
      PFASs at age 5 years were associated with increased odds of asthma at ages 5 and 
      13. The associations were reversed among MMR-vaccinated children. Prenatal PFAS 
      exposure was not associated with childhood asthma or allergic diseases regardless 
      of MMR vaccination status. In conclusion, PFAS exposure at age 5 was associated 
      with increased risk of asthma among a small subgroup of MMR-unvaccinated children 
      but not among MMR-vaccinated children. While PFAS exposure may impact immune 
      system functions, this study suggests that MMR vaccination might be a potential 
      effect-modifier.
FAU - Timmermann, Clara Amalie Gade
AU  - Timmermann CA
AD  - a Department of Environmental Medicine , University of Southern Denmark , Odense 
      , Denmark.
FAU - Budtz-Jorgensen, Esben
AU  - Budtz-Jorgensen E
AD  - b Section of Biostatistics , University of Copenhagen , Copenhagen , Denmark.
FAU - Jensen, Tina Kold
AU  - Jensen TK
AD  - a Department of Environmental Medicine , University of Southern Denmark , Odense 
      , Denmark.
FAU - Osuna, Christa Elyse
AU  - Osuna CE
AD  - c Center for Virology and Vaccine Research , Beth Israel Deaconess Medical 
      Center, Harvard Medical School , Boston , MA , USA.
FAU - Petersen, Maria Skaalum
AU  - Petersen MS
AD  - d Department of Occupational Medicine and Public Health , Faroe Islands, Denmark.
FAU - Steuerwald, Ulrike
AU  - Steuerwald U
AD  - d Department of Occupational Medicine and Public Health , Faroe Islands, Denmark.
FAU - Nielsen, Flemming
AU  - Nielsen F
AD  - a Department of Environmental Medicine , University of Southern Denmark , Odense 
      , Denmark.
FAU - Poulsen, Lars K
AU  - Poulsen LK
AD  - e Allergy Clinic , Copenhagen University Hospital Gentofte , Hellerup , Denmark.
FAU - Weihe, Pal
AU  - Weihe P
AD  - d Department of Occupational Medicine and Public Health , Faroe Islands, Denmark.
AD  - f Faculty of Natural and Health Sciences , University of the Faroe Islands , 
      Faroe Islands, Denmark.
FAU - Grandjean, Philippe
AU  - Grandjean P
AD  - a Department of Environmental Medicine , University of Southern Denmark , Odense 
      , Denmark.
AD  - g Department of Environmental Health , Harvard T.H. Chan School of Public Health 
      , Boston , MA , USA.
LA  - eng
GR  - R01 ES012199/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20170116
PL  - England
TA  - J Immunotoxicol
JT  - Journal of immunotoxicology
JID - 101201960
RN  - 0 (Fluorocarbons)
RN  - 0 (Measles-Mumps-Rubella Vaccine)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Asthma/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Denmark
MH  - Environmental Exposure/adverse effects
MH  - Female
MH  - Fluorocarbons/*adverse effects
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Measles-Mumps-Rubella Vaccine/*immunology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*immunology
MH  - Skin Tests
MH  - Vaccination
PMC - PMC6190697
MID - NIHMS990083
OTO - NOTNLM
OT  - Allergy
OT  - MMR vaccination
OT  - asthma
OT  - children
OT  - perfluoroalkyl substances
COIS- Declaration of interest The authors report no conflict of interests. The authors 
      alone are responsible for the content of this manuscript.
EDAT- 2017/01/17 06:00
MHDA- 2017/10/14 06:00
PMCR- 2018/10/16
CRDT- 2017/01/17 06:00
PHST- 2017/01/17 06:00 [pubmed]
PHST- 2017/10/14 06:00 [medline]
PHST- 2017/01/17 06:00 [entrez]
PHST- 2018/10/16 00:00 [pmc-release]
AID - 10.1080/1547691X.2016.1254306 [doi]
PST - ppublish
SO  - J Immunotoxicol. 2017 Dec;14(1):39-49. doi: 10.1080/1547691X.2016.1254306. Epub 
      2017 Jan 16.