PMID- 28092581 OWN - NLM STAT- MEDLINE DCOM- 20190118 LR - 20190118 IS - 2168-2208 (Electronic) IS - 2168-2194 (Linking) VI - 22 IP - 2 DP - 2018 Mar TI - An Integrated Maximum Current Density Approach for Noninvasive Detection of Myocardial Infarction. PG - 495-502 LID - 10.1109/JBHI.2017.2649570 [doi] AB - We present a new approach of integrated maximum current density (IMCD) for the noninvasive detection of myocardial infarction (MI) using magnetocardiography (MCG) data acquired from a superconducting quantum interference device (SQUID) system. In this paper, we investigated the relationship of the maximum current density (MCD) in the current density map and the underlying equivalent current dipole (ECD) based on a novel method of reconstructing the ECD in the extremum circle of the magnetic field map. The performance of IMCD and the integrated ECD (IECD) approaches were also evaluated by using 61-channel MCG data from 39 healthy subjects and 102 patients with ST elevation myocardial infarction (STEMI). Statistical analysis of the healthy and STEMI groups demonstrate that the IMCD approach obtains sensitivity and specificity up to 91.2% and 84.6%, somewhat higher than that of IECD, respectively. The results indicate that IMCD provides spatiotemporal information regarding cardiac electrical activity during ventricular repolarization. This approach may be helpful to diagnose MI in clinic application. The physical concept of the approach is also explained in this paper. FAU - Zhao, Chen AU - Zhao C FAU - Jiang, Shiqin AU - Jiang S FAU - Wu, Yanhua AU - Wu Y FAU - Zhu, Junjie AU - Zhu J FAU - Zhou, Dafang AU - Zhou D FAU - Hailer, Birgit AU - Hailer B FAU - Gronemeyer, Dietrich AU - Gronemeyer D FAU - Van Leeuwen, Peter AU - Van Leeuwen P LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20170106 PL - United States TA - IEEE J Biomed Health Inform JT - IEEE journal of biomedical and health informatics JID - 101604520 SB - IM MH - Databases, Factual MH - Humans MH - Magnetocardiography/*methods MH - Myocardial Infarction/*diagnosis MH - *Signal Processing, Computer-Assisted EDAT- 2017/01/17 06:00 MHDA- 2019/01/19 06:00 CRDT- 2017/01/17 06:00 PHST- 2017/01/17 06:00 [pubmed] PHST- 2019/01/19 06:00 [medline] PHST- 2017/01/17 06:00 [entrez] AID - 10.1109/JBHI.2017.2649570 [doi] PST - ppublish SO - IEEE J Biomed Health Inform. 2018 Mar;22(2):495-502. doi: 10.1109/JBHI.2017.2649570. Epub 2017 Jan 6.