PMID- 28093081
OWN - NLM
STAT- MEDLINE
DCOM- 20171024
LR  - 20221207
IS  - 1944-446X (Electronic)
IS  - 1000-467X (Print)
IS  - 1944-446X (Linking)
VI  - 36
IP  - 1
DP  - 2017 Jan 16
TI  - The most important questions in cancer research and clinical oncology : Question 
      1. Could the vertical transmission of human papilloma virus (HPV) infection 
      account for the cause, characteristics, and epidemiology of HPV-positive 
      oropharyngeal carcinoma, non-smoking East Asian female lung adenocarcinoma, 
      and/or East Asian triple-negative breast carcinoma?
PG  - 13
LID - 10.1186/s40880-016-0168-1 [doi]
LID - 13
AB  - Specific research foci: (1) Mouse models of gamma-herpes virus-68 (gammaHV-68) and 
      polyomavirus (PyV) infections during neonatal versus adult life. (2) For human 
      papilloma virus (HPV)-positive oropharyngeal carcinoma (OPC)-(a) Asking the 
      question: Is oral sex a powerful carcinogen? (b) Examining the evidence for the 
      vertical transmission of HPV infection. (c) Examining the relationship between 
      HPV and Epstein-Barr virus (EBV) infections and nasopharyngeal cancer (NPC) in 
      West European, East European, and East Asian countries. (d) Examining the 
      association between HPV-positive OPC and human leukocyte antigen (HLA). (3) For 
      non-smoking East Asian female lung adenocarcinoma-(a) Examining the incidence 
      trends of HPV-positive OPC and female lung adenocarcinoma according to birth 
      cohorts. (b) Examining the association between female lung adenocarcinoma and 
      HPV. (c) Examining the associations of lung adenocarcinoma with immune modulating 
      factors. (4) For triple-negative breast carcinoma (TNBC) in East Asians-(a) 
      Examining the association between TNBC and HPV. (b) Examining the unique 
      epidemiological characteristics of patients with TNBC. A summary 
      "epidemiological" model tying some of these findings together.
FAU - Wee, Joseph T S
AU  - Wee JT
AD  - Division of Radiation Oncology, National Cancer Centre, Singapore, 169610, 
      Singapore. Joseph.wee.t.s@singhealth.com.sg.
AD  - Duke-NUS Medical School, Singapore, 169857, Singapore. 
      Joseph.wee.t.s@singhealth.com.sg.
FAU - Poh, Sharon Shuxian
AU  - Poh SS
AD  - Division of Radiation Oncology, National Cancer Centre, Singapore, 169610, 
      Singapore.
LA  - eng
PT  - News
DEP - 20170116
PL  - England
TA  - Chin J Cancer
JT  - Chinese journal of cancer
JID - 101498232
SB  - IM
MH  - Adenocarcinoma/*epidemiology/virology
MH  - Adenocarcinoma of Lung
MH  - Animals
MH  - Disease Models, Animal
MH  - Asia, Eastern/epidemiology
MH  - Female
MH  - Humans
MH  - Infectious Disease Transmission, Vertical
MH  - Lung Neoplasms/*epidemiology/virology
MH  - Mice
MH  - Oropharyngeal Neoplasms/*epidemiology/virology
MH  - Papillomavirus Infections/*transmission
MH  - Triple Negative Breast Neoplasms/*epidemiology/virology
PMC - PMC5240210
EDAT- 2017/01/18 06:00
MHDA- 2017/10/25 06:00
PMCR- 2017/01/16
CRDT- 2017/01/18 06:00
PHST- 2016/08/16 00:00 [received]
PHST- 2016/11/20 00:00 [accepted]
PHST- 2017/01/18 06:00 [entrez]
PHST- 2017/01/18 06:00 [pubmed]
PHST- 2017/10/25 06:00 [medline]
PHST- 2017/01/16 00:00 [pmc-release]
AID - 10.1186/s40880-016-0168-1 [pii]
AID - 168 [pii]
AID - 10.1186/s40880-016-0168-1 [doi]
PST - epublish
SO  - Chin J Cancer. 2017 Jan 16;36(1):13. doi: 10.1186/s40880-016-0168-1.