PMID- 28093570
OWN - NLM
STAT- MEDLINE
DCOM- 20171218
LR  - 20220310
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 41
IP  - 4
DP  - 2017 Apr
TI  - Vitamin D administration, cognitive function, BBB permeability and 
      neuroinflammatory factors in high-fat diet-induced obese rats.
PG  - 639-644
LID - 10.1038/ijo.2017.10 [doi]
AB  - OBJECTIVES: The purpose of this research was to investigate the effects of 
      vitamin D administration on cognitive function, nuclear factor-kappaB (NF-kappaB), 
      brain-derived neurotrophic factor (BDNF) concentration in the hippocampus and 
      blood-brain barrier (BBB) permeability in high-fat diet (HFD)-induced obese rats. 
      METHODS: Male Wistar rats were fed either a control diet or HFD for 16 weeks 
      (n=20); then, each group was randomized into two subgroups supplemented orally 
      with 500 IU kg(-1) vitamin D for 5 weeks. A Morris water maze (MWM) test was 
      performed at the 21st week to examine cognitive function. BBB permeability was 
      characterized by Evans blue dye in the hippocampus. BDNF and NF-kappaB concentrations 
      in the hippocampus and serum vitamin D concentrations were also measured. 
      RESULTS: HFD led to a significant delay in escape latency time and reduced time 
      of MWM probe test because of increased NF-kappaB and decreased BDNF concentrations in 
      the hippocampus. Vitamin D supplementation in the HFD group significantly reduced 
      body weight, NF-kappaB concentrations, BBB permeability and increased BDNF 
      concentrations in the hippocampus. CONCLUSIONS: Vitamin D reversed HFD-induced 
      cognitive impairments by reduction of the NF-kappaB and elevation of BDNF 
      concentrations and modulation of the BBB permeability in rats' hippocampus.
FAU - Hajiluian, G
AU  - Hajiluian G
AD  - Nutrition Research Center, Department of Community Nutrition, Tabriz University 
      of Medical Sciences, Tabriz, Iran.
FAU - Nameni, G
AU  - Nameni G
AD  - Nutrition Research Center, Department of Community Nutrition, Tabriz University 
      of Medical Sciences, Tabriz, Iran.
FAU - Shahabi, P
AU  - Shahabi P
AD  - Department of Physiology, School of Medical Sciences, Tabriz University of 
      Medical Sciences, Tabriz, Iran.
FAU - Mesgari-Abbasi, M
AU  - Mesgari-Abbasi M
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Sadigh-Eteghad, S
AU  - Sadigh-Eteghad S
AD  - Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, 
      Tabriz, Iran.
FAU - Farhangi, M A
AU  - Farhangi MA
AD  - Nutrition Research Center, Department of Community Nutrition, Tabriz University 
      of Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170117
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Inflammation Mediators)
RN  - 0 (NF-kappa B)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Vitamins)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*drug effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/*drug effects
MH  - *Diet, High-Fat
MH  - Energy Metabolism
MH  - Hippocampus/drug effects/*metabolism/pathology
MH  - Inflammation Mediators/*metabolism
MH  - Male
MH  - NF-kappa B/metabolism
MH  - Nerve Tissue Proteins/metabolism
MH  - Obesity/*metabolism/pathology
MH  - Permeability
MH  - Rats
MH  - Rats, Wistar
MH  - Vitamin D/*pharmacology
MH  - Vitamins/pharmacology
EDAT- 2017/01/18 06:00
MHDA- 2017/12/19 06:00
CRDT- 2017/01/18 06:00
PHST- 2016/07/20 00:00 [received]
PHST- 2016/11/22 00:00 [revised]
PHST- 2016/12/17 00:00 [accepted]
PHST- 2017/01/18 06:00 [pubmed]
PHST- 2017/12/19 06:00 [medline]
PHST- 2017/01/18 06:00 [entrez]
AID - ijo201710 [pii]
AID - 10.1038/ijo.2017.10 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2017 Apr;41(4):639-644. doi: 10.1038/ijo.2017.10. Epub 2017 
      Jan 17.