PMID- 28093778
OWN - NLM
STAT- MEDLINE
DCOM- 20171019
LR  - 20171019
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 56
IP  - 5
DP  - 2017 Nov
TI  - Brainstem reflex excitability changes in patients with amyotrophic lateral 
      sclerosis.
PG  - 925-929
LID - 10.1002/mus.25580 [doi]
AB  - INTRODUCTION: In this study we explored brainstem reflex excitability changes, 
      blink reflex recovery cycles (BRRCs), and masseter inhibitory reflexes (MIRs) in 
      patients with amyotrophic lateral sclerosis (ALS). METHODS: Fourteen ALS patients 
      and 14 healthy control subjects were recruited. The BRRC was examined at 
      interstimulus intervals (ISIs) of 100, 200, 300, 400, 500, and 600 ms. The 
      latencies and durations of silent period 1 (SP1) and silent period 2 (SP2) of the 
      MIR were measured. RESULTS: Decreased R2 area suppression was prominent in the 
      ALS group at ISIs of 200, 300, and 400 ms (P < 0.02), whereas no significant 
      differences between groups at 100, 500, and 600 ms ISIs (P > 0.05) were observed. 
      SP2 duration was significantly prolonged in the ALS group compared with controls 
      (P = 0.01). CONCLUSIONS: Brainstem inhibitory and excitatory interneuronal 
      activity is altered in ALS, possibly brought about by physiological and 
      morphological changes at the cortical or bulbar levels. Muscle Nerve 56: 925-929, 
      2017.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Cengiz, Bulent
AU  - Cengiz B
AD  - Department of Neurology, Division of Clinical Neurophysiology, Gazi University 
      Faculty of Medicine, Besevler, 06500, Ankara, Turkey.
FAU - Ercan, Merve Bahar
AU  - Ercan MB
AD  - Department of Neurology, Division of Clinical Neurophysiology, Gazi University 
      Faculty of Medicine, Besevler, 06500, Ankara, Turkey.
FAU - Iskender, Mustafa
AU  - Iskender M
AD  - Department of Neurology, Division of Clinical Neurophysiology, Gazi University 
      Faculty of Medicine, Besevler, 06500, Ankara, Turkey.
FAU - Kuruoglu, Hidayet Reha
AU  - Kuruoglu HR
AD  - Department of Neurology, Division of Clinical Neurophysiology, Gazi University 
      Faculty of Medicine, Besevler, 06500, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170318
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Aged
MH  - Amyotrophic Lateral Sclerosis/*pathology
MH  - Blinking/*physiology
MH  - Brain Stem/*physiopathology
MH  - Case-Control Studies
MH  - Electromyography
MH  - Female
MH  - Functional Laterality
MH  - Humans
MH  - Male
MH  - Masseter Muscle/*physiopathology
MH  - Middle Aged
MH  - Reaction Time/physiology
MH  - Statistics as Topic
MH  - Time Factors
OTO - NOTNLM
OT  - ALS
OT  - blink reflex recovery cycle
OT  - brainstem reflex
OT  - excitability
OT  - masseter inhibitory reflex
EDAT- 2017/01/18 06:00
MHDA- 2017/10/20 06:00
CRDT- 2017/01/18 06:00
PHST- 2016/07/26 00:00 [received]
PHST- 2017/01/09 00:00 [revised]
PHST- 2017/01/11 00:00 [accepted]
PHST- 2017/01/18 06:00 [pubmed]
PHST- 2017/10/20 06:00 [medline]
PHST- 2017/01/18 06:00 [entrez]
AID - 10.1002/mus.25580 [doi]
PST - ppublish
SO  - Muscle Nerve. 2017 Nov;56(5):925-929. doi: 10.1002/mus.25580. Epub 2017 Mar 18.