PMID- 28094283
OWN - NLM
STAT- MEDLINE
DCOM- 20180323
LR  - 20200701
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 42
IP  - 8
DP  - 2017 Jul
TI  - Adolescent Chronic Unpredictable Stress Exposure Is a Sensitive Window for 
      Long-Term Changes in Adult Behavior in Mice.
PG  - 1670-1678
LID - 10.1038/npp.2017.11 [doi]
AB  - Adolescence is a time period in development when the brain undergoes substantial 
      remodeling in response to the environment. To determine whether a stressful 
      experience during adolescence affects adult behavior, we exposed adolescent male 
      and female C57BL/6J mice to chronic unpredictable stress (CUS) for 12 days 
      starting at postnatal day 28 (PND28). We also exposed adult male and female mice 
      to CUS for 12 days beginning at PND70 to determine whether adolescence is a 
      sensitive time period when stress can have long-lasting effects on behavior. 
      Regardless of when mice were exposed to stress, they were all tested exactly 30 
      days later in the marble burying task, elevated zero maze, acoustic startle 
      response, and forced swim test. Adolescent stress exposure increased anxiety-like 
      behaviors in adult male and female mice and decreased acoustic startle response 
      in a sex-dependent manner. However, adult stress exposure did not change anxiety 
      or response to an acoustic tone in adult male or female mice as compared with 
      nonstressed animals. Of interest, increased depression-like behavior in the 
      forced swim test was observed in all mice, regardless of when the stress 
      occurred. Gene expression analysis showed significant upregulation of 
      corticotropin releasing factor receptor 2 (CrfR2) in the amygdala of males 
      subjected to CUS during adolescence, but not in males that experienced CUS during 
      adulthood. In contrast, females, regardless of when they were exposed to CUS, 
      were not affected. These data support clinical evidence suggesting that 
      early-life stress may predispose individuals to increased anxiety and depression 
      later in life.
FAU - Yohn, Nicole L
AU  - Yohn NL
AD  - Department of Systems Pharmacology and Translational Therapeutics, Perelman 
      School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Blendy, Julie A
AU  - Blendy JA
AD  - Department of Systems Pharmacology and Translational Therapeutics, Perelman 
      School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
LA  - eng
GR  - F32 DA005589/DA/NIDA NIH HHS/United States
GR  - R01 DA033646/DA/NIDA NIH HHS/United States
GR  - T32 DA028874/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20170117
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (CRF receptor type 2)
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
SB  - IM
MH  - Aging/*psychology
MH  - Amygdala/metabolism
MH  - Animals
MH  - *Behavior, Animal
MH  - *Critical Period, Psychological
MH  - Female
MH  - Male
MH  - Mice
MH  - Receptors, Corticotropin-Releasing Hormone/biosynthesis
MH  - Reflex, Startle
MH  - Sex Characteristics
MH  - Stress, Psychological/*psychology
PMC - PMC5518894
EDAT- 2017/01/18 06:00
MHDA- 2018/03/24 06:00
PMCR- 2017/07/01
CRDT- 2017/01/18 06:00
PHST- 2016/07/11 00:00 [received]
PHST- 2016/12/14 00:00 [revised]
PHST- 2017/01/02 00:00 [accepted]
PHST- 2017/01/18 06:00 [pubmed]
PHST- 2018/03/24 06:00 [medline]
PHST- 2017/01/18 06:00 [entrez]
PHST- 2017/07/01 00:00 [pmc-release]
AID - npp201711 [pii]
AID - 10.1038/npp.2017.11 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2017 Jul;42(8):1670-1678. doi: 10.1038/npp.2017.11. Epub 
      2017 Jan 17.