PMID- 28094793
OWN - NLM
STAT- MEDLINE
DCOM- 20181114
LR  - 20181114
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 8
DP  - 2017 Jan 17
TI  - Caloric restriction improves health and survival of rhesus monkeys.
PG  - 14063
LID - 10.1038/ncomms14063 [doi]
LID - 14063
AB  - Caloric restriction (CR) without malnutrition extends lifespan and delays the 
      onset of age-related disorders in most species but its impact in nonhuman 
      primates has been controversial. In the late 1980s two parallel studies were 
      initiated to determine the effect of CR in rhesus monkeys. The University of 
      Wisconsin study reported a significant positive impact of CR on survival, but the 
      National Institute on Aging study detected no significant survival effect. Here 
      we present a direct comparison of longitudinal data from both studies including 
      survival, bodyweight, food intake, fasting glucose levels and age-related 
      morbidity. We describe differences in study design that could contribute to 
      differences in outcomes, and we report species specificity in the impact of CR in 
      terms of optimal onset and diet. Taken together these data confirm that health 
      benefits of CR are conserved in monkeys and suggest that CR mechanisms are likely 
      translatable to human health.
FAU - Mattison, Julie A
AU  - Mattison JA
AD  - Translational Gerontology Branch, National Institute on Aging, Baltimore, 
      Maryland 21224, USA.
FAU - Colman, Ricki J
AU  - Colman RJ
AD  - Wisconsin National Primate Research Center, University of Wisconsin-Madison, 
      Madison, Wisconsin 53715, USA.
FAU - Beasley, T Mark
AU  - Beasley TM
AD  - Department of Biostatistics, University of Alabama, Birmingham, Alabama 35294, 
      USA.
AD  - Geriatric Research Education and Clinical Center, Birmingham/Atlanta Veterans 
      Administration Hospital, Birmingham, Alabama 35233, USA.
FAU - Allison, David B
AU  - Allison DB
AD  - Department of Biostatistics, University of Alabama, Birmingham, Alabama 35294, 
      USA.
FAU - Kemnitz, Joseph W
AU  - Kemnitz JW
AD  - Wisconsin National Primate Research Center, University of Wisconsin-Madison, 
      Madison, Wisconsin 53715, USA.
AD  - Department of Cell and Regenerative Biology, University of Wisconsin-Madison, 
      Madison, Wisconsin 53792, USA.
FAU - Roth, George S
AU  - Roth GS
AD  - GeroScience, Pylesville, Maryland 21323, USA.
FAU - Ingram, Donald K
AU  - Ingram DK
AD  - Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
FAU - Weindruch, Richard
AU  - Weindruch R
AD  - Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA.
AD  - Geriatric Research Education and Clinical Center, William S. Middleton Memorial 
      Veterans Hospital, Madison, Wisconsin 53705, USA.
FAU - de Cabo, Rafael
AU  - de Cabo R
AUID- ORCID: 0000-0002-3354-2442
AD  - Translational Gerontology Branch, National Institute on Aging, Baltimore, 
      Maryland 21224, USA.
FAU - Anderson, Rozalyn M
AU  - Anderson RM
AD  - Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA.
AD  - Geriatric Research Education and Clinical Center, William S. Middleton Memorial 
      Veterans Hospital, Madison, Wisconsin 53705, USA.
LA  - eng
GR  - P51 RR000167/RR/NCRR NIH HHS/United States
GR  - R01 AG037000/AG/NIA NIH HHS/United States
GR  - R01 AG040178/AG/NIA NIH HHS/United States
GR  - R56 AG047358/AG/NIA NIH HHS/United States
GR  - P01 AG011915/AG/NIA NIH HHS/United States
GR  - P30 DK056336/DK/NIDDK NIH HHS/United States
GR  - P51 OD011106/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170117
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - *Caloric Restriction
MH  - Diet
MH  - Energy Intake
MH  - Female
MH  - Longevity
MH  - Longitudinal Studies
MH  - Macaca mulatta/growth & development/*metabolism
MH  - Male
PMC - PMC5247583
COIS- R.W. is a member of the board of LifeGen Technologies, a company focused on 
      nutritional genomics. G.S.R. is Chief Executive Officer of GeroScience, Inc. and 
      Vice President of Prolongevity Technologies. D.K.I. serves as Chief Scientific 
      Officer for GeroScience, Inc., and Prolongevity Technologies, Inc. D.B.A. serves 
      on the board of IKEA and has received consulting fees from multiple government, 
      not for profit, and for profit organizations with interests in obesity and 
      nutrition. None of these activities benefit directly from this research and no 
      competing financial interests are declared. The remaining authors declare no 
      competing financial interests.
EDAT- 2017/01/18 06:00
MHDA- 2018/11/15 06:00
PMCR- 2017/01/17
CRDT- 2017/01/18 06:00
PHST- 2016/05/31 00:00 [received]
PHST- 2016/11/24 00:00 [accepted]
PHST- 2017/01/18 06:00 [entrez]
PHST- 2017/01/18 06:00 [pubmed]
PHST- 2018/11/15 06:00 [medline]
PHST- 2017/01/17 00:00 [pmc-release]
AID - ncomms14063 [pii]
AID - 10.1038/ncomms14063 [doi]
PST - epublish
SO  - Nat Commun. 2017 Jan 17;8:14063. doi: 10.1038/ncomms14063.