PMID- 28095424
OWN - NLM
STAT- MEDLINE
DCOM- 20170808
LR  - 20240327
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 1
DP  - 2017
TI  - Investigation of Inclusion Complex of Patchouli Alcohol with beta-Cyclodextrin.
PG  - e0169578
LID - 10.1371/journal.pone.0169578 [doi]
LID - e0169578
AB  - The objective of this study was to improve the stability and water-solubility of 
      patchouli alcohol by complexing with beta-cyclodextrin (beta-CD). The interactions 
      between patchouli alcohol and beta-CD were characterized by differential scanning 
      calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder 
      X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. 
      According to molecular modeling method, the enthalpy formation of host-guest 
      illustrated the predominant configuration and the lowest value DeltabGo was 
      -10.8174+/-1.9235 kcal/mol, suggesting the complex could reduce the energy of the 
      system. The characterization analysis confirmed the formation of PA-CD inclusion 
      complex, and the results indicated the advantage of the inclusion complex in 
      stability and dissolution rates. These results identified PA-CD inclusion complex 
      an effective way for the storage of PA, and better inclusion method still needed 
      to be studied.
FAU - Xu, Fangfang
AU  - Xu F
AD  - The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
      Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
FAU - Yang, Qiuxia
AU  - Yang Q
AD  - The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
      Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
AD  - Guangdong Pharmaceutical University, College of Traditional Chinese Medicine, 
      Guangzhou, China.
FAU - Wu, Lilan
AU  - Wu L
AD  - The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
      Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
FAU - Qi, Rui
AU  - Qi R
AD  - The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
      Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
FAU - Wu, Yunshan
AU  - Wu Y
AD  - The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
      Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
FAU - Li, Yucui
AU  - Li Y
AD  - College of Chinese Medicines, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Tang, Lipeng
AU  - Tang L
AD  - The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
      Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
FAU - Guo, De-An
AU  - Guo DA
AD  - The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
      Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
AD  - Guangdong Pharmaceutical University, College of Traditional Chinese Medicine, 
      Guangzhou, China.
AD  - Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike 
      Road, Shanghai, China.
FAU - Liu, Bo
AU  - Liu B
AD  - The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 
      Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20170117
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Sesquiterpenes)
RN  - 0 (beta-Cyclodextrins)
RN  - HHH8CPR1M2 (patchouli alcohol)
SB  - IM
MH  - Calorimetry, Differential Scanning
MH  - Inclusion Bodies/*chemistry/*metabolism
MH  - Models, Molecular
MH  - Sesquiterpenes/*chemistry/*metabolism
MH  - Solubility
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Thermodynamics
MH  - X-Ray Diffraction
MH  - beta-Cyclodextrins/*chemistry/*metabolism
PMC - PMC5240955
COIS- The authors have declared that no competing interests exist.
EDAT- 2017/01/18 06:00
MHDA- 2017/08/09 06:00
PMCR- 2017/01/17
CRDT- 2017/01/18 06:00
PHST- 2016/08/09 00:00 [received]
PHST- 2016/12/05 00:00 [accepted]
PHST- 2017/01/18 06:00 [entrez]
PHST- 2017/01/18 06:00 [pubmed]
PHST- 2017/08/09 06:00 [medline]
PHST- 2017/01/17 00:00 [pmc-release]
AID - PONE-D-16-28616 [pii]
AID - 10.1371/journal.pone.0169578 [doi]
PST - epublish
SO  - PLoS One. 2017 Jan 17;12(1):e0169578. doi: 10.1371/journal.pone.0169578. 
      eCollection 2017.