PMID- 28097792
OWN - NLM
STAT- MEDLINE
DCOM- 20170914
LR  - 20170914
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 64
IP  - 8
DP  - 2017 Aug
TI  - FISH identifies a KAT6A/CREBBP fusion caused by a cryptic insertional t(8;16) in 
      a case of spontaneously remitting congenital acute myeloid leukemia with a normal 
      karyotype.
LID - 10.1002/pbc.26450 [doi]
AB  - Cytogenetics can inform risk stratification in pediatric acute myeloid leukemia 
      (AML). We describe the first case of a newborn with leukemia cutis found to have 
      AML harboring a cryptic insertional t(8;16)(p11.2;p13.3) with associated 
      KAT6A/CREBBP fusion identified exclusively by fluorescence in situ hybridization 
      (FISH). Expectant management resulted in spontaneous leukemia resolution. The 
      identification of t(8;16)(p11.2;p13.3) may serve as a biomarker for spontaneous 
      remission in congenital AML. FISH for this translocation is warranted in 
      congenital AML with a normal karyotype, and patients with KAT6A/CREBBP fusion 
      should be conservatively managed. While 50% of spontaneously remitting congenital 
      AML with t(8;16)(p11.2;p13.3) may recur, high salvage rates are attained with 
      standard therapy.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Barrett, Rachel
AU  - Barrett R
AD  - Department of Pediatrics, IWK Health Centre/Dalhousie University, Halifax, Nova 
      Scotia, Canada.
FAU - Morash, Barbara
AU  - Morash B
AD  - Department of Pathology, IWK Health Centre/Dalhousie University, Halifax, Nova 
      Scotia, Canada.
FAU - Roback, David
AU  - Roback D
AD  - Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.
FAU - Pambrun, Chantale
AU  - Pambrun C
AD  - Department of Pathology, IWK Health Centre/Dalhousie University, Halifax, Nova 
      Scotia, Canada.
FAU - Marfleet, Lesley
AU  - Marfleet L
AD  - Division of Hematology/Oncology, Department of Pediatrics, IWK Health Centre, 
      Halifax, Nova Scotia, Canada.
FAU - Ketterling, Rhett P
AU  - Ketterling RP
AD  - Division of Hematopathology, Mayo Clinic College of Medicine, Rochester, 
      Minnesota.
FAU - Harrison, Karen
AU  - Harrison K
AD  - Department of Pathology, IWK Health Centre/Dalhousie University, Halifax, Nova 
      Scotia, Canada.
FAU - Berman, Jason N
AU  - Berman JN
AD  - Department of Pediatrics, IWK Health Centre/Dalhousie University, Halifax, Nova 
      Scotia, Canada.
AD  - Department of Pathology, IWK Health Centre/Dalhousie University, Halifax, Nova 
      Scotia, Canada.
AD  - Division of Hematology/Oncology, Department of Pediatrics, IWK Health Centre, 
      Halifax, Nova Scotia, Canada.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170118
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
RN  - 0 (Oncogene Proteins, Fusion)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.3.1.48 (CREBBP protein, human)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (KAT6A protein, human)
SB  - IM
MH  - CREB-Binding Protein/*genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - Female
MH  - Histone Acetyltransferases/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant, Newborn
MH  - Karyotype
MH  - Leukemia, Myeloid, Acute/*congenital/*genetics
MH  - Neoplasm Regression, Spontaneous/*genetics
MH  - Oncogene Proteins, Fusion/genetics
MH  - Translocation, Genetic/*genetics
OTO - NOTNLM
OT  - AML
OT  - KAT6A/CREBBP
OT  - biomarker
OT  - congenital
OT  - t(8;16)
OT  - translocation
EDAT- 2017/01/18 06:00
MHDA- 2017/09/15 06:00
CRDT- 2017/01/19 06:00
PHST- 2016/09/26 00:00 [received]
PHST- 2016/11/22 00:00 [revised]
PHST- 2016/12/17 00:00 [accepted]
PHST- 2017/01/18 06:00 [pubmed]
PHST- 2017/09/15 06:00 [medline]
PHST- 2017/01/19 06:00 [entrez]
AID - 10.1002/pbc.26450 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2017 Aug;64(8). doi: 10.1002/pbc.26450. Epub 2017 Jan 18.