PMID- 28099880
OWN - NLM
STAT- MEDLINE
DCOM- 20170329
LR  - 20200106
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 57
DP  - 2017 Apr
TI  - Modifications of inhibitory transmission onto pyramidal neurons by postnatal 
      exposure to MK-801: Effects of enriched environment.
PG  - 56-61
LID - S0736-5748(16)30257-X [pii]
LID - 10.1016/j.ijdevneu.2017.01.006 [doi]
AB  - Early enriched environment (EE) prevents several deficits associated with 
      postnatal MK-801 [N-Methyl-d-Aspartate (NMDA) receptor antagonist] treatment such 
      as cognitive and locomotor deficits. We sought physiological correlates to such 
      changes by looking at inhibitory synaptic inputs onto pyramidal cells in a 
      prefrontal cortex slice preparation. Pharmacologically isolated gamma-amino-butyric 
      acid (A) (GABA(A)) receptor-mediated currents were measured using whole-cell 
      patch clamp recordings. Wistar rats were raised in standard or EE from birth up 
      to the time of experiments and were injected with saline or MK-801 (1mg/kg) on 
      postnatal days (P) 6-10. We recorded miniature inhibitory post-synaptic currents 
      (mIPSCs) of pyramidal cells in layer II/III of prefrontal cortex and measured 
      their frequency, amplitude and kinetics. In control animals, the amplitude and 
      frequency of mIPSCs increased strikingly during development from P21 to P28. 
      MK-801 accelerated the development of mIPSCs frequency but caused a significant 
      decrease in the amplitude of mIPSCs on P28 suggesting a significant reduction of 
      inhibition onto pyramidal cells. EE per se led to a significant increase in both 
      frequency and amplitude of mIPSCs, but its application to MK-801-treated rats 
      resulted in moderate rescue of GABAergic transmission on P28. We conclude that 
      postnatal MK-801 leads to reduced inhibitory transmission onto pyramidal cells of 
      prefrontal cortex at adolescence which may underlie behavioural and morphological 
      differences detected in vivo in rats. EE presentation from birth rather prevents 
      GABAergic alterations associated with postnatal MK-801 treatment at adolescence.
CI  - Copyright (c) 2017 ISDN. Published by Elsevier Ltd. All rights reserved.
FAU - Shojaei, Amir
AU  - Shojaei A
AD  - Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares 
      University, Tehran, Iran.
FAU - Anaraki, Afsaneh Kamali
AU  - Anaraki AK
AD  - Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares 
      University, Tehran, Iran.
FAU - Mirnajafi-Zadeh, Javad
AU  - Mirnajafi-Zadeh J
AD  - Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares 
      University, Tehran, Iran.
FAU - Atapour, Nafiseh
AU  - Atapour N
AD  - Neuroscience Research Center, Neuropharmacology Institute, Kerman University of 
      Medical Sciences, Kerman, Iran; Neuroscience Program, Monash Biomedicine 
      Discovery Institute and Department of Physiology, Monash University, Melbourne, 
      Victoria 3800, Australia. Electronic address: nafiseh.atapour@monash.edu.
LA  - eng
PT  - Journal Article
DEP - 20170115
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (GABA-A Receptor Antagonists)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Bicuculline/pharmacology
MH  - Dizocilpine Maleate/*pharmacology
MH  - Electric Stimulation
MH  - *Environment
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - Female
MH  - GABA-A Receptor Antagonists/pharmacology
MH  - In Vitro Techniques
MH  - Inhibitory Postsynaptic Potentials/*drug effects
MH  - Male
MH  - Patch-Clamp Techniques
MH  - Prefrontal Cortex/*cytology
MH  - Pregnancy
MH  - Pyramidal Cells/*drug effects
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Development
OT  - Enriched environment
OT  - Inhibitory synaptic currents
OT  - NMDA receptor antagonist
OT  - Prefrontal cortex
OT  - Schizophrenia
EDAT- 2017/01/19 06:00
MHDA- 2017/03/31 06:00
CRDT- 2017/01/19 06:00
PHST- 2016/09/20 00:00 [received]
PHST- 2017/01/12 00:00 [revised]
PHST- 2017/01/12 00:00 [accepted]
PHST- 2017/01/19 06:00 [pubmed]
PHST- 2017/03/31 06:00 [medline]
PHST- 2017/01/19 06:00 [entrez]
AID - S0736-5748(16)30257-X [pii]
AID - 10.1016/j.ijdevneu.2017.01.006 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2017 Apr;57:56-61. doi: 10.1016/j.ijdevneu.2017.01.006. Epub 
      2017 Jan 15.